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首页> 外文期刊>Journal of pharmaceutical sciences. >Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier.
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Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier.

机译：母婴间抗病毒药物的转移以及转运蛋白参与胎盘屏障。

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摘要

Administration of antiviral drugs to pregnant women with influenza, human immunodeficiency virus (HIV), and herpes simplex virus (HSV) infections is widely accepted as an effective treatment to safeguard the health of the mother and fetus. This review deals with the transfer of antiviral drugs to the fetus across the placental barrier, which is formed by an epithelial layer of syncytiotrophoblasts. First, the structure, function, and developmental change of the placenta and the placental barrier are briefly presented. We then review the transplacental permeability of antiviral drugs, such as oseltamivir for influenza, antiretrovirals (e.g., zidovudine, didanosine, and saquinavir) for HIV, and acyclovir for HSV, focusing on the involvement of ATP-binding cassette, organic anion/cation, and nucleoside transporters. The increasing evidence that is becoming available about transport mechanisms operating at the placental barrier is expected to be useful in the development of techniques to control fetal and placental transfer of antiviral drugs, and thereby to obtain maximum therapeutic benefit while minimizing potential fetal toxicity.
机译：对患有流感，人类免疫缺陷病毒（HIV）和单纯疱疹病毒（HSV）感染的孕妇服用抗病毒药物已被公认为是保护母亲和胎儿健康的有效疗法。这项审查涉及抗病毒药物通过胎盘屏障由胎儿合体滋养层细胞的上皮层形成向胎儿的转移。首先，简要介绍胎盘和胎盘屏障的结构，功能和发育变化。然后，我们回顾抗病毒药物的经胎盘通透性，例如奥司他韦治疗流感，抗逆转录病毒药物（例如齐多夫定，去羟肌苷和沙奎那韦）用于HIV，无环鸟苷用于HSV，重点研究了ATP结合盒，有机阴离子/阳离子，和核苷转运蛋白。关于在胎盘屏障处起作用的转运机制的越来越多的证据有望用于开发控制胎儿和胎盘抗病毒药物转移的技术，从而在最大程度地降低胎儿毒性的同时获得最大的治疗益处。

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