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首页> 外文期刊>Journal of pharmaceutical sciences. >Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid.
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Physicochemical stability of solid dispersions of enantiomeric or racemic ibuprofen in stearic acid.

机译：对映体或外消旋布洛芬在硬脂酸中的固体分散体的理化稳定性。

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摘要

The aim of this study was to investigate the solid dispersion phase behavior of s- or rs-ibuprofen in stearic acid. By means of thermal analysis, we have demonstrated the total immiscibility, in solid state, of the corresponding binary mixtures. This indicates that no specific interactions exist between the chosen excipient and active pharmaceutical ingredient (API) that lead to eutectic systems. Furthermore, based on calorimetric and X-ray diffraction experiments, we have showed that upon cooling of the molten state, only stearic acid recrystallizes in the presence of s-ibuprofen, whereas a quaternary phase mixture is obtained for the racemic ibuprofen/stearic acid preparation. The solubility of stearic acid in s-ibuprofen liquid in all proportions was also determined. Overall, the results presented here offer an approach for the study of API/excipient interactions.
机译：本研究的目的是研究s-或rs-布洛芬在硬脂酸中的固体分散相行为。通过热分析，我们证明了相应的二元混合物在固态下的完全不混溶。这表明所选择的赋形剂与导致共晶系统的活性药物成分（API）之间不存在特定的相互作用。此外，基于量热法和X射线衍射实验，我们已经表明，在冷却熔融态时，只有硬脂酸在s-布洛芬存在下才能重结晶，而外消旋布洛芬/硬脂酸制备则获得季相混合物。还测定了硬脂酸在s-布洛芬液体中的所有比例的溶解度。总体而言，此处提供的结果为API /辅料相互作用的研究提供了一种方法。

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