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首页> 外文期刊>Journal of pharmaceutical sciences. >Novel Amorphous Microporous Silica Spheres for Controlled Release Applications
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Novel Amorphous Microporous Silica Spheres for Controlled Release Applications

机译：用于控释应用的新型非晶态微孔二氧化硅球

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摘要

A new synthesis route for large spherical particles of amorphous microporous silica (AMS) was developed. These novel spherical porous particles with diameter of around 100 mum and pore diameter smaller than 2 nm were prepared using an oil drop method. Molten ibuprofen was successfully loaded into the AMS pores. In vitro release experiments revealed that ibuprofen was released from the spheres via a slow pore diffusion process lasting up to 14 days. Experimentally determined diffusion coefficients of ibuprofen in the porous spheres were of the order of 10~(-15)-10~(-16) m~2 s~(-1). The present findings reveal the potential of AMS spheres for controlled release of small drug molecules over long time periods. The spherical shape of the AMS particles is advantageous in formulation processes as it provides adequate powder flow properties and reliable release profiles.
机译：开发了一种新的合成方法，用于合成大球形无定形微孔二氧化硅（AMS）。使用油滴法制备这些直径约100μm且孔径小于2nm的新型球形多孔颗粒。熔融的布洛芬已成功装入AMS孔中。体外释放实验表明，布洛芬通过持续长达14天的缓慢孔扩散过程从球体中释放出来。实验确定的布洛芬在多孔球中的扩散系数约为10〜（-15）-10〜（-16）m〜2 s〜（-1）。目前的发现揭示了AMS球在长期控制小药物分子释放方面的潜力。 AMS颗粒的球形在配制过程中是有利的，因为它提供了足够的粉末流动性和可靠的释放特性。

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