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首页> 外文期刊>Journal of pharmaceutical sciences. >Two-Dimensional pH Mapping of Release Kinetics of Silica-Encapsulated Drugs
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Two-Dimensional pH Mapping of Release Kinetics of Silica-Encapsulated Drugs

机译：硅胶包裹药物释放动力学的二维pH映射

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摘要

The encapsulation of pharmaceutical drug molecules in silica gels during the sol-gel synthesis and their kinetic release profile in aqueous solutions were systematically investigated in dependence of synthesis pH(S) and extraction pH(E) values. Six pH values in the range from 1 to 6 were chosen in a 6 x 6 two-dimensional matrix to screen the first-order initial dissolution rate constant and the total amount of released drug. Characteristic differences are discovered in such two-dimensional pH mapping profiles for the molecules with different ionization behavior and they are explained by surface imprinting and encapsulation processes. Remarkably, these encapsulations must occur either in the particles of the sol solutions or during the rapid liquid-solid transition of the spray-drying process employed in this study. This pH mapping method is suggested as a novel tool to probe noncovalent imprinting and encapsulation processes in sol-gel-derived materials with embedded guest molecules.
机译：根据合成pH（S）和萃取pH（E）值，系统研究了溶胶-凝胶合成过程中药物分子在硅胶中的包封及其在水溶液中的动力学释放曲线。在6 x 6二维矩阵中选择1到6范围内的六个pH值，以筛选一阶初始溶出速率常数和释放的药物总量。在具有不同电离行为的分子的此类二维pH映射图中发现了特性差异，并通过表面压印和封装过程对其进行了解释。值得注意的是，这些包封必须在溶胶溶液的颗粒中或在本研究中使用的喷雾干燥过程的快速液体-固体转变过程中发生。该pH映射方法被建议作为一种新型工具，用于探测具有嵌入的客体分子的溶胶-凝胶衍生材料中的非共价印迹和封装过程。

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