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首页> 外文期刊>Journal of pharmaceutical sciences. >Scale-up of nanoemulsion produced by emulsification and solvent diffusion
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Scale-up of nanoemulsion produced by emulsification and solvent diffusion

机译：乳化和溶剂扩散产生的纳米乳液按比例放大

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摘要

The scale-up of nanoemulsions (NEs) produced by emulsification and solvent diffusion process was successfully achieved in the present work. Up to 1500 mL of NEs were produced with olive oil, castor oil, almond oil, or Arlamol? E by using a Y-shaped mixer device. NE droplet sizes were significantly modulated from 290 to 185 nm by changing the process parameters without modification of the formulation composition. Smaller NE droplet sizes were obtained by (1) decreasing the internal diameter of the Y-mixer from 5 to 0.8 mm, (2) increasing the flow rates of the organic and the aqueous phases upon mixing, and (3) increasing the temperature of the experiment from 5°C to 40°C. All the results of NE diameters (d sc) expressed as a function of the Reynolds number (Re) and the shear rate inside the Y-mixer, respectively. The existence of these power-laws for NE formation by emulsification and solvent diffusion process has never been reported in the literature yet and constitutes a new finding in this work. We definitely proved that the high turbulences created upon NE formation are the most important parameter allowing to decrease droplet size.
机译：在本工作中，成功实现了通过乳化和溶剂扩散工艺生产的纳米乳剂的规模放大。用橄榄油，蓖麻油，杏仁油或Arlamol？可以生产多达1500 mL的NE。 E通过使用Y形混合器设备。通过改变工艺参数而不改变配方组成，可将NE液滴的大小从290 nm调节至185 nm。通过（1）将Y混合器的内径从5毫米减小到0.8毫米，（2）混合时增加有机相和水相的流速以及（3）升高温度来获得较小的NE液滴尺寸。实验温度为5°C至40°C。 NE直径的所有结果（d sc）分别表示为Y混合器内部的雷诺数（Re）和剪切速率的函数。这些通过乳化和溶剂扩散过程形成NE的幂律的存在尚未在文献中报道，这构成了这项工作的新发现。我们绝对证明，在NE形成时产生的高湍流是允许减小液滴尺寸的最重要参数。

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