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首页> 外文期刊>Journal of pharmaceutical sciences. >Effect of polymer molecular weight on the production of drug nanoparticles.
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Effect of polymer molecular weight on the production of drug nanoparticles.

机译：聚合物分子量对药物纳米颗粒生产的影响。

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摘要

Stable, polymer-coated nanoparticles of two hydrophobic drugs, namely nabumetone and halofantrine, have been prepared by a wet-bead milling process performed in the presence of a stabilizing homopolymer, either hydroxypropylmethylcellulose (HPMC) or polyvinylpyrrolidone (PVP), of differing molecular weights and concentrations. Although nabumetone nanoparticles could only be produced when HPMC was used as stabilizing polymer, halofantrine nanoparticles could be prepared using either HPMC or PVP. Stable nanoparticles of nabumetone could be produced using a HPMC solution of viscosity average molecular weight, M(v), of 5 kg/mol over an approximate four fold polymer concentration range (0.63-2.5% w/w) when a drug loading of 20% w/w was used. Increasing the molecular weight of HPMC up to a limiting M(v) of 89 kg/mol did not result in the formation of nanoparticles at any of the polymer concentrations examined. The amount of polymer absorbed onto the nanoparticles was determined by measuring the depletion of polymer from solution based on either an ultra-violet (PVP) or optical rotatory dispersion (ORD) (HPMC) assay. The slightly lower concentration of HMPC found to be present on the surface of the halofantrine nanoparticles compared with the nabumetone nanoparticles suggested a differing affinity of the polymer for the surface of the two drugs.
机译：通过在不同分子量的稳定均聚物（羟丙基甲基纤维素（HPMC）或聚乙烯吡咯烷酮（PVP））存在下进行的湿珠研磨工艺，制备了萘丁美酮和氟丁汀两种疏水性药物的稳定的聚合物包覆纳米颗粒。和浓度。尽管仅当将HPMC用作稳定聚合物时才能生产萘丁美酮纳米颗粒，但是可以使用HPMC或PVP制备卤芬汀纳米颗粒。当载药量为20时，在大约四倍的聚合物浓度范围内（0.63-2.5％w / w），使用粘均分子量M（v）为5 kg / mol的HPMC溶液可以制备萘丁美酮的稳定纳米颗粒使用％w / w。将HPMC的分子量增加到89 kg / mol的极限M（v）不会导致在所检查的任何聚合物浓度下都形成纳米颗粒。通过基于紫外线（PVP）或旋光分散体（ORD）（HPMC）分析测量溶液中聚合物的消耗量，确定吸收到纳米颗粒上的聚合物的量。与萘丁美酮纳米颗粒相比，发现在氟番嘌呤纳米颗粒表面上存在的HMPC浓度稍低，这表明聚合物对两种药物表面的亲和力不同。

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