• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of pharmaceutical sciences. >Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery.
【24h】

Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery.

机译：电场介导的基因传递过程中实体瘤中的场分布和DNA转运。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gene therapy has a great potential in cancer treatment. However, the efficacy of cancer gene therapy is currently limited by the lack of a safe and efficient means to deliver therapeutic genes into the nucleus of tumor cells. One method under investigation for improving local gene delivery is based on the use of pulsed electric field. Despite repeated demonstration of its effectiveness in vivo, the underlying mechanisms behind electric field-mediated gene delivery remain largely unknown. Without a thorough understanding of these mechanisms, it will be difficult to further advance the gene delivery. In this review, the electric field-mediated gene delivery in solid tumors will be examined by following individual transport processes that must occur in vivo for a successful gene transfer. The topics of examination include: (i) major barriers for gene delivery in the body, (ii) distribution of electric fields at both cell and tissue levels during the application of external fields, and (iii) electric field-induced transport of genes across each of the barriers. Through this approach, the review summarizes what is known about the mechanisms behind electric field-mediated gene delivery and what require further investigations in future studies.
机译：基因治疗在癌症治疗中具有巨大潜力。然而，由于缺乏将治疗基因递送到肿瘤细胞核中的安全有效的手段，癌症基因治疗的功效目前受到限制。一种正在研究的用于改善局部基因递送的方法是基于脉冲电场的使用。尽管反复证明了其在体内的有效性，但电场介导的基因传递背后的潜在机制仍然未知。没有对这些机制的透彻了解，将难以进一步推进基因传递。在这篇综述中，实体肿瘤中电场介导的基因传递将通过遵循必须在体内成功进行基因转移的单个转运过程进行检查。审查的主题包括：（i）体内基因传递的主要障碍;（ii）在施加外场期间细胞和组织水平上电场的分布;以及（iii）电场诱导的基因在细胞内的转运每个障碍。通过这种方法，本综述总结了有关电场介导的基因传递背后机制的已知知识，以及在未来研究中需要进一步研究的内容。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号