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首页> 外文期刊>Journal of pharmaceutical sciences. >Impact of screw elements on continuous granulation with a twin-screw extruder.
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Impact of screw elements on continuous granulation with a twin-screw extruder.

机译：螺杆元件对双螺杆挤出机连续造粒的影响。

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摘要

The influence of different screw element types on wet granulation process with a twin-screw extruder was investigated. Lactose granules were prepared with different screw configurations such as conveying, combing mixer and kneading elements. The use of kneading blocks led to an almost complete agglomeration of lactose, whereas kneading and combing mixer elements resulted in smaller granules in comparison. Granule porosity varied between 17.4% and 50.6%. Granule friability values ranged from 1.2% to 38.5%. Conveying elements led to the most porous and friable granules, whereas kneading blocks produced the densest and least friable granules. Combing mixer elements produced granules with median properties. A linear correlation between granule porosity and the natural logarithm of granule friability was detected. Flowability of granules was also influenced by the element type. Compressed granules with higher granule porosities resulted in tablets with higher tensile strength values and vice versa. Twin-screw extruders proved to be a versatile tool for wet granulation. By the choice of a suitable screw element granule and tablet characteristics were influenced.
机译：研究了双螺杆挤出机中不同螺杆元件类型对湿法制粒过程的影响。制备具有不同螺杆构造的乳糖颗粒，例如输送，梳理混合器和捏合元件。捏合块的使用导致乳糖几乎完全团聚，而相比之下，捏合和梳理混合器元件会产生更小的颗粒。颗粒孔隙率在17.4％和50.6％之间变化。颗粒脆性值的范围为1.2％至38.5％。输送元件产生最多孔和最脆的颗粒，而捏合块产生最致密和最不脆的颗粒。梳理混合器元件产生具有中值性质的颗粒。检测到颗粒孔隙率与颗粒易碎性的自然对数之间存在线性关系。颗粒的流动性也受元素类型的影响。具有较高颗粒孔隙率的压缩颗粒产生具有较高拉伸强度值的片剂，反之亦然。事实证明，双螺杆挤出机是湿法制粒的多功能工具。通过选择合适的螺杆元件颗粒和片剂特性受到影响。

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