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首页> 外文期刊>Journal of pharmacokinetics and biopharmaceutics >Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method.
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Analysis of nonlinear and nonsteady state hepatic extraction with the dispersion model using the finite difference method.

机译：使用有限差分法用色散模型分析非线性和非稳态肝提取。

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摘要

A numerical calculation method for dispersion models was developed to analyze nonlinear and nonsteady hepatic elimination of substances. The finite difference method (FDM), a standard numerical calculation technique, was utilized to solve nonlinear partial differential equations of the dispersion model. Using this method, flexible application of the dispersion model becomes possible, because (i) nonlinear kinetics can be incorporated anywhere, (ii) the input function can be altered arbitrarily, and (iii) the number of compartments can be increased as needed. This method was implemented in a multipurpose nonlinear least-squares fitting computer program, Napp (Numeric Analysis Program for Pharmacokinetics). We simulated dilution curves for several nonlinear two-compartment hepatic models in which the saturable process is assumed in transport or metabolism, and investigated whether they could definitely be discriminated from each other. Preliminary analysis of the rat liver perfusion data of a cyclic pentapeptide, BQ-123, was performed by this method to demonstrate its applicability.
机译：开发了一种弥散模型的数值计算方法，以分析物质的非线性和非稳态肝清除。有限差分法（FDM）是一种标准数值计算技术，用于求解色散模型的非线性偏微分方程。使用此方法，可以灵活应用色散模型，因为（i）非线性动力学可以在任何地方合并，（ii）输入函数可以任意更改，并且（iii）可以根据需要增加隔室的数量。该方法是在多用途非线性最小二乘拟合计算机程序Napp（药物动力学数值分析程序）中实现的。我们模拟了几种非线性的两室肝模型的稀释曲线，在该模型中，在运输或新陈代谢过程中均采用了可饱和过程，并研究了它们是否可以明确地区分。通过这种方法初步分析了环状五肽BQ-123在大鼠肝脏的灌注数据，以证明其适用性。

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