Note: caution in use of empirical equations for pharmacodynamic indirect response models.

Krzyzanski W; Jusko WJ

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Note: caution in use of empirical equations for pharmacodynamic indirect response models.

机译：注意：在药效学间接反应模型中使用经验公式时要谨慎。

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An empirical equation was recently proposed and used to characterize inhibitory drug effects on production of an endogenous substance. The limitations of this empirical equation are described utilizing mathematical equations and simulations based on the exact differential equation for Indirect Response Model I. The latter is preferable for fitting data using indirect response models.

机译：最近提出了一个经验方程，并用来表征抑制药物对内源性物质产生的影响。使用数学方程式和基于精确响应方程的间接响应模型I的模拟来描述此经验方程式的局限性。后者更适合使用间接响应模型拟合数据。

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《Journal of pharmacokinetics and biopharmaceutics》 |1998年第6期|共7页
作者
Krzyzanski W; Jusko WJ;
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正文语种 eng
中图分类药学;
关键词
Models; Biological; Pharmacokinetics; 模型; 生物学; 药代动力学;

机译：Models;Biological;Pharmacokinetics;模型;生物学;药代动力学;

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Note: caution in use of empirical equations for pharmacodynamic indirect response models.

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