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首页> 外文期刊>Journal of pharmacokinetics and biopharmaceutics >A compartmental analysis of the pharmacokinetics of propofol in sheep.
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A compartmental analysis of the pharmacokinetics of propofol in sheep.

机译：丙泊酚在绵羊体内药代动力学的分区分析。

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摘要

Conventional compartmental pharmacokinetic analysis may provide inaccurate prediction of drug concentrations after rapid i.v. administration. To examine this, compartment and effect compartment analysis was applied to measured arterial and brain concentrations of propofol in sheep after i.v. administration at a range of doses and dose rates. Although arterial and brain concentrations were reasonably well fitted to compartmental and effect compartment models for individual doses and dose rates, the structure and parameters of all models differed with changes in both dose and rate of administration. There were large discrepancies between predicted and measured arterial and brain concentrations when these models were used to predict drug concentrations across doses and dose rates. These data support the limitations of this type of modeling in the setting of rapid propofol administration.
机译：在快速静脉注射后，常规的区室药代动力学分析可能无法准确预测药物浓度。行政。为了检查这一点，将隔室和效果隔室分析应用于静脉注射后绵羊中丙泊酚的动脉和大脑浓度测量值。以一定的剂量和剂量率给药。尽管对于单独的剂量和剂量率，动脉和大脑的浓度已很好地适合于隔室和效应隔室模型，但所有模型的结构和参数都随剂量和给药率的变化而不同。当使用这些模型预测不同剂量和剂量率下的药物浓度时，在预测和测量的动脉和大脑浓度之间存在很大差异。这些数据支持了这种类型的建模在快速异丙酚给药中的局限性。

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