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首页> 外文期刊>Journal of pharmaceutical sciences. >The effect of the physical state of binders on high-shear wet granulation and granule properties: A mechanistic approach to understand the high-shear wet granulation process. part IV. the impact of rheological state and tip-speeds
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The effect of the physical state of binders on high-shear wet granulation and granule properties: A mechanistic approach to understand the high-shear wet granulation process. part IV. the impact of rheological state and tip-speeds

机译：粘合剂的物理状态对高剪切湿法制粒和颗粒性质的影响：一种了解高剪切湿法制粒过程的机械方法。第四部分流变状态和叶尖速度的影响

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The purpose of this study is to provide a mechanistic understanding concerning the effect of tip-speed on a granulation at various binder rheological states; the in situ rheological state of a binder was controlled by exposing a granulation blend to 96% relative humidity. This approach allowed us to investigate the impact of tip-speed on granule consolidation coupled with the in situ binder state, which was not possible using a conventional granulation approach. Experimentally, the rheological state of binders was characterized using a rheometer. Granule size and granule porosity were measured by Qicpic instrument and Mercury Intrusion Porosimetry, respectively. For the granulations containing binders at viscous state (PVP K17 and PVP K29/32), the granule size increased significantly with mixing time and the growth rate increased with tip-speed until 5.8 m/s; when binders were at viscoelastic state, tip-speed had no impact on granulation. Furthermore, the granule porosity was higher for granulation with binders at viscoelastic state (HPC and PVP K90), whereas it was lower for granulation with binders at viscous state. In addition, the impeller tip-speed had minimal impact on the porosity of the final granules. Finally, Ennis' model was used for interpreting results, providing mechanistic insights on granulation.
机译：这项研究的目的是提供一种有关尖端速度对各种粘结剂流变状态下造粒的影响的机理的理解。通过将制粒共混物暴露于96％相对湿度来控制粘合剂的原位流变状态。这种方法使我们能够研究尖端速度对颗粒固结以及原位粘合剂状态的影响，这是使用常规制粒方法无法实现的。实验上，使用流变仪表征了粘合剂的流变状态。分别通过Qicpic仪器和Mercury Intrusion Porosimetry测量颗粒尺寸和颗粒孔隙率。对于含有处于粘性状态的粘合剂的颗粒（PVP K17和PVP K29 / 32），随着混合时间的延长，颗粒尺寸显着增加，直至尖端速度达到5.8 m / s时，其增长率才随着尖端速度的增加而增加。当粘合剂处于粘弹性状态时，尖端速度对造粒没有影响。此外，对于在粘弹性状态下的粘合剂制粒（HPC和PVP K90）而言，颗粒孔隙率较高，而对于在粘性状态下的粘合剂制粒则较低。此外，叶轮的叶尖速度对最终颗粒的孔隙率影响很小。最后，使用恩尼斯（Ennis）模型解释结果，从而提供有关制粒的机械见解。

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