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首页> 外文期刊>Journal of pharmaceutical sciences. >Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state.
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Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state.

机译：非晶态药物-PVP分散体：理论，热学和光谱分析技术在研究具有结晶和纯非晶态分子间键的分子中的应用。

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摘要

We report the case of BMS-488043-PVP solid dispersions which when analysed using modulated DSC showed compliance with the Gordon-Taylor model, confirming ideal mixing behaviour of the two components. The nature or presence of stabilising interactions between drug and PVP could not be confirmed using this technique. Use of FT-IR, Raman and solid-state NMR spectroscopy confirmed the presence of stabilising hydrogen bond interactions between the drug and PVP. Similar interactions are present as intermolecular bonds in the crystalline and pure amorphous drug system. The Gordon-Taylor equation, as it is not predictive of the presence of intermolecular bonds such as hydrogen bonding in an amorphous dispersion, may underestimate the likely physical stability of solid dispersions which are produced and stabilised by these interactions.
机译：我们报告了BMS-488043-PVP固体分散体的情况，该固体分散体在使用调制DSC进行分析时显示符合Gordon-Taylor模型，确认了两种组分的理想混合行为。使用这种技术无法确定药物与PVP之间稳定相互作用的性质或存在。 FT-IR，拉曼光谱和固态NMR光谱的使用证实了药物与PVP之间存在稳定的氢键相互作用。类似的相互作用作为分子间键存在于结晶和纯无定形药物系统中。 Gordon-Taylor方程无法预测无定形分散体中是否存在分子间键（例如氢键），因此可能会低估通过这些相互作用产生并稳定的固体分散体的可能的物理稳定性。

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