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首页> 外文期刊>Journal of pharmaceutical sciences. >Liquid-liquid miscibility gaps and hydrate formation in drug-water binary systems: pressure-temperature phase diagram of lidocaine and pressure-temperature-composition phase diagram of the lidocaine-water system.
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Liquid-liquid miscibility gaps and hydrate formation in drug-water binary systems: pressure-temperature phase diagram of lidocaine and pressure-temperature-composition phase diagram of the lidocaine-water system.

机译：药物-水二元系统中的液-液混溶间隙和水合物形成：利多卡因的压力-温度相图和利多卡因-水系统的压力-温度-组成相图。

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摘要

The pressure-temperature (P-T) melting curve of lidocaine was determined (dP/dT = 3.56 MPa K(-1)), and the lidocaine-water system was investigated as a function of temperature and pressure. The lidocaine-water system exhibits a monotectic equilibrium at 321 K (ordinary pressure) whose temperature increases as the pressure increases until the two liquids become miscible. A hydrate, unstable at ordinary pressure, was shown to form, on increasing the pressure, from about 70 MPa at low temperatures (200-300 K). The thermodynamic conditions of its stability were inferred from the location of the three-phase equilibria involving the hydrate in the lidocaine-water pressure-temperature-mole fraction (P-T-x) diagram.
机译：确定了利多卡因的压力-温度（P-T）熔融曲线（dP / dT = 3.56 MPa K（-1）），并研究了利多卡因-水系统随温度和压力的变化。利多卡因-水系统在321 K（常压）下表现出单晶平衡，温度随着压力的升高而升高，直到两种液体互溶为止。在常压下不稳定的水合物显示出，在升高压力时，在低温（200-300 K）下从约70 MPa开始形成水合物。从利多卡因-水-压力-温度-摩尔分数（P-T-x）图中涉及水合物的三相平衡的位置推断出其稳定性的热力学条件。

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