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首页> 外文期刊>Journal of pharmacokinetics and biopharmaceutics >Rapid attainment of steady state plasma drug concentrations within precise limits.
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Rapid attainment of steady state plasma drug concentrations within precise limits.

机译：在精确限制内快速达到稳态血浆药物浓度。

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摘要

We describe a method of rapidly obtaining a specified steady state plasma concentration of an intravenous drug within precise limits. The technique requires an initial bolus to raise the plasma concentration to the upper limit followed by a series of constant-rate infusions each of which is associated with a minimum plasma concentration equal to the lower limit. The infusion rate is stepped down when the plasma concentration returns to the upper limit. Computer simulation, based on the method, is used to generate plasma concentration-time curves with fluctuations of up to 10% about selected steady state concentrations of amrinone, esmolol, lidocaine, midazolam, propofol, and theophylline. The utility of this general approach to intravenous dosing and potential limitations of the method are discussed.
机译：我们描述了一种在精确范围内快速获得静脉药物的指定稳态血浆浓度的方法。该技术需要初始推注以将血浆浓度提高到上限，然后进行一系列恒定速率的输液，每次输注均与等于下限的最小血浆浓度相关。当血浆浓度恢复到上限时，输注速率会降低。基于该方法的计算机模拟用于生成血浆浓度-时间曲线，其中所选的氨力农，艾司洛尔，利多卡因，咪达唑仑，丙泊酚和茶碱的稳态浓度波动最高可达10％。讨论了这种一般方法在静脉内给药的实用性以及该方法的潜在局限性。

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