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首页> 外文期刊>Journal of Perinatal Medicine >Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.
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Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.

机译：可溶性细胞间粘附分子和C反应蛋白是新生儿感染的早期标志物。

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摘要

In order to find a reliable early marker of infection in newborns a study with simultaneous determination of soluble Intercellular Adhesion Molecule-1 (sICAM-1) and C-Reactive Protein (CRP) was planned. Prospectively 90 babies < 5 days of age suspect of infection were included. Retrospectively this population was classified into an "infected" group (n = 45) and a "non-infected" group (n = 45). For each of these two groups we calculated the sensitivity, specificity and predictive values of sICAM-1 and CRP as early markers of infection. We determined the best cut-off level for sICAM-1 to be 300 micrograms/l and for CRP 5 mg/l. As a biochemical test for infection in the newborns the sensitivity and negative predictive value for CRP were 0.69 and 0.73 respectively. When sICAM-1 was added and CRP and s-ICAM-1 were used in combination the sensitivity improved significantly to 0.93, p < 0.01 and the negative predictive value improved to 0.92, p < 0.05. In normal 5-8 days old babies' sICAM-1 was significantly higher than at birth (cord blood), p < 0.0001. In conclusion, sICAM-1 and CRP in combination are better than CRP as a primary test for identification of infection in babies < 5 days of age.
机译：为了找到新生儿感染的可靠早期标志物，计划同时测定可溶性细胞间粘附分子1（sICAM-1）和C反应蛋白（CRP）的研究。包括90位5岁以下的可疑感染婴儿。回顾性地将该人群分为“感染”组（n = 45）和“未感染”组（n = 45）。对于这两组，我们计算了sICAM-1和CRP作为感染早期标志物的敏感性，特异性和预测值。我们确定sICAM-1的最佳临界水平为300微克/升，CRP为5毫克/升。作为新生儿感染的生化测试，CRP的敏感性和阴性预测值分别为0.69和0.73。当添加sICAM-1并结合使用CRP和s-ICAM-1时，灵敏度显着提高至0.93，p <0.01，阴性预测值提高至0.92，p <0.05。在正常的5-8天大婴儿的sICAM-1显着高于出生时（脐带血），p ​​<0.0001。总之，sICAM-1和CRP的组合比CRP更好，可作为5岁以下婴儿识别感染的主要测试方法。

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