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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Relation between structural and release properties in a polysaccharide gel system
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Relation between structural and release properties in a polysaccharide gel system

机译：多糖凝胶体系中结构与释放性能之间的关系

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摘要

The potential utility of kappa-carrageenan gels for preparing drug release devices is here shown. Structural properties of kappa-carrageenan gels 14 prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and theological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is IF possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by kappa-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems. (c) 2007 Elsevier B.V. All rights reserved.
机译：此处显示了κ-角叉菜胶凝胶在制备药物释放装置中的潜在用途。已经通过静态光散射和神学测量评估了用不同盐组成制备的并含有酮洛芬钠盐作为模型药物的κ-角叉菜胶14的结构性质。这些特性与pH 5.5下的体外释放曲线相关。已将凝胶基质的释放特性与包含相同药物的两种市售产品的释放特性进行了比较。结果表明：i）在该系统中，可以通过使用不同的阳离子浓度轻松控制凝胶质地; ii）κ-角叉菜胶凝胶释放药物的动力学取决于基质的结构特性; iii）在典型的局部应用间隔时间中，所有凝胶样品几乎完全释放了负载的药物，这与市售产品有所不同。所有这些发现可以为经典的局部释放系统的实现提供有用的建议。 （c）2007 Elsevier B.V.保留所有权利。

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