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首页> 外文期刊>Journal of perinatology: Official journal of the California Perinatal Association >Use of polymerase chain reaction as a diagnostic tool for neonatal sepsis can result in a decrease in use of antibiotics and total neonatal intensive care unit length of stay.
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Use of polymerase chain reaction as a diagnostic tool for neonatal sepsis can result in a decrease in use of antibiotics and total neonatal intensive care unit length of stay.

机译：使用聚合酶链反应作为新生儿败血症的诊断工具可能会导致抗生素使用减少以及新生儿重症监护病房的总住院时间减少。

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OBJECTIVE: To retrospectively determine if a negative 16S ribosomal RNA (rRNA) polymerase chain reaction (PCR) (PCR(-)) could lead to a decrease in the number of antibiotic doses and neonatal intensive care unit (NICU) length of stay (LOS) for infants admitted to the NICU for presumed early-onset sepsis (EOS) with negative blood culture results (BC(-)). STUDY DESIGN: Analysis included 419 infants, greater than 35 weeks gestational age, with PCR(-), BC(-) and LOS > 48 h. Both the investigators and clinical care team were unaware of the PCR results. The actual number of antibiotic doses (AAD) administered was compared to an estimated number of antibiotics doses (EAD) that would have been given until PCR(-) results were available by 18 h. The number of antibiotic doses saved was calculated as (AAD-EAD). The actual NICU LOS in hours (aLOS) for a subset of infants who remained in the hospital primarily for antibiotic therapy was compared to an estimated LOS (eLOS) if infants with PCR(-) were discharged fromthe NICU when clinically stable. The number of hours saved was calculated as (aLOS-eLOS). RESULTS: Approximately eight antibiotic doses and 85 NICU hours per infant could be saved using PCR(-) results available at 18 h. CONCLUSIONS: Use of 16S rRNA PCR could decrease the number of antibiotics doses and NICU LOS for infants admitted for EOS. This may facilitate: (1) earlier NICU discharge; (2) parental satisfaction; and (3) decreased health care costs.
机译：目的：回顾性地确定阴性的16S核糖体RNA（rRNA）聚合酶链反应（PCR）（PCR（-））是否可导致减少抗生素剂量和减少新生儿重症监护病房（NICU）的住院时间（LOS） ）适用于因血液培养结果阴性（BC（-））而被推测为早发性败血症（EOS）的NICU婴儿。研究设计：分析包括419个胎龄大于35周的婴儿，其PCR（-），BC（-）和LOS> 48 h。研究人员和临床护理团队都不了解PCR结果。将实际施用的抗生素剂量（AAD）与估计的抗生素剂量（EAD）进行比较，直到18 h可获得PCR（-）结果之前，应一直使用。节省的抗生素剂量计算为（AAD-EAD）。如果临床上稳定时从NICU出院的PCR（-）婴儿离开医院，但主要用于抗生素治疗的一部分婴儿的实际NICU小时小时数（aLOS）与估计LOS（eLOS）进行了比较。节省的小时数计算为（aLOS-eLOS）。结果：使用18小时可获得的PCR（-）结果，每名婴儿可以节省大约8种抗生素剂量和85个NICU小时。结论：使用16S rRNA PCR可以减少EOS婴儿的抗生素剂量和NICU LOS。这可能有助于：（1）早期重症监护病房出院; （2）父母的满意程度; （3）降低了医疗费用。

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