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首页> 外文期刊>Journal of Periodontology >Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta-tricalcium phosphate bone substitute or bovine-derived xenograft.
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Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/beta-tricalcium phosphate bone substitute or bovine-derived xenograft.

机译：单独使用引导的组织再生和自体海绵或结合羟基磷灰石/β-磷酸三钙骨替代物或牛源异种移植物治疗骨内缺损。

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BACKGROUND: The aim of this case-control study was to investigate the clinical regeneration of deep intrabony defects using guided tissue regeneration (GTR) with autogenous spongiosa (ASB) alone or using GTR with a mixture of ASB with a bovine-derived xenograft (BDX) or a synthetic composite bone substitute (hydroxyapatite/beta-tricalcium phosphate [HA/beta-TCP]). METHODS: Sixty-four patients with a total of 93 intrabony defects of 2- or 3-wall morphology and an intrabony component (IC)>or=4 mm participated in this study. Defects were treated with a bioabsorbable membrane and ASB alone or ASB mixed with HA/beta-TCP or BDX. Clinical parameters measured at baseline and 12 months after surgery included IC, bleeding on probing (BOP), and plaque accumulation (PLI). Vertical bone gain (VBG) and percentage relative bone gain (RBG) were used as indicators of treatment efficacy. A stringent plaque control regimen was enforced in all patients during the 12-month observation period. RESULTS: At baseline, no statistically significant differences in any of the clinical parameters were observed between the groups. At 12 months, HA/beta-TCP and BDX treatments produced similar improvements in intrabony tissue regeneration as shown by VBG (P=0.616) and RBG (P=0.826) with significantly better outcomes than ASB alone (P<0.0001). Changes in BOP and PLI did not differ significantly between the groups. CONCLUSION: The combined use of ASB with BDX or HA/beta-TCP led to significantly greater gain of clinical attachment and hard tissue formation compared to the use of ASB alone.
机译：背景：本病例对照研究的目的是研究单独使用自发性海绵体（ASB）的引导组织再生（GTR）或将ATR与牛源异种移植物（BDX）混合使用GTR进行深部骨内缺损的临床再生）或合成的合成骨替代品（羟基磷灰石/β-磷酸三钙[HA /β-TCP]）。方法：本研究共纳入了64例具有2或3壁形态的骨内缺陷且骨内成分（IC）> == 4 mm的患者。缺陷用生物可吸收膜和单独的ASB或与HA / beta-TCP或BDX混合的ASB进行处理。在基线和手术后12个月测量的临床参数包括IC，探查出血（BOP）和斑块积聚（PLI）。垂直骨增量（VBG）和相对骨增量百分比（RBG）用作治疗功效的指标。在12个月的观察期内，所有患者均实施了严格的菌斑控制方案。结果：在基线时，两组之间在任何临床参数上均未观察到统计学上的显着差异。在12个月时，HA / beta-TCP和BDX治疗对骨骼内组织再生产生了类似的改善，如VBG（P = 0.616）和RBG（P = 0.826）所示，其结果明显优于单纯ASB（P <0.0001）。两组之间的BOP和PLI变化无明显差异。结论：与单独使用ASB相比，将ASB与BDX或HA / beta-TCP组合使用可显着提高临床依从性和硬组织形成。

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