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首页> 外文期刊>Journal of Periodontology >Adhesion of Porphyromonas gingivalis strains to cultured epithelial cells from patients with a history of chronic adult periodontitis or from patients less susceptible to periodontitis.
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Adhesion of Porphyromonas gingivalis strains to cultured epithelial cells from patients with a history of chronic adult periodontitis or from patients less susceptible to periodontitis.

机译：牙龈卟啉单胞菌菌株对具有慢性成人牙周炎病史的患者或对牙周炎不敏感的患者对培养的上皮细胞的粘附。

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BACKGROUND: The present study aimed to explain the interindividual variation in periodontitis susceptibility by differences in the initial adhesion rate of Porphyromonas gingivalis to the pocket epithelium of these individuals, and/or by inter-P. gingivalis strain differences in association capacity (adhesion and internalization). METHODS: Adhesion assays were performed on epithelial monolayers (cultured in vitro from pocket epithelium belonging to patients who were less or more susceptible to chronic adult periodontitis) using 11 genetically different clinical strains of P. gingivalis. RESULTS: Both the disease category (less susceptible versus susceptible) and the interstrain variation were found to have a significant effect (both P <0.05) on the initial bacterial association. The chronic adult periodontitis group showed significantly more association of P. gingivalis when compared to less susceptible patients (4.2 x 10(6) versus 3.5 x 10(6)). Also, the interstrain variation was significant, with strains Pg 4 and 5 representing the least and best associating bacteria (1.8 x 10(6) colony forming units for Pg 4, 9 x 10(6) for Pg 5). CONCLUSIONS: These results indicate that periodontitis susceptibility is influenced by both the interindividual differences in pocket epithelium (allowing more adhesion of P. gingivalis) or by the strain type by which the patient is infected (intra-species differences in adhesion capacity).
机译：背景：本研究旨在通过牙龈卟啉单胞菌对这些个体口袋上皮的初始黏附率的差异和/或inter-P来解释牙周炎易感性的个体差异。牙龈炎应变能力（粘附力和内在化）的差异。方法：使用11种基因不同的临床牙龈卟啉单胞菌菌株对上皮单层（从属于对成人慢性牙周炎较不敏感或较敏感的患者的袋状上皮细胞进行体外培养）进行粘附测定。结果：发现疾病种类（易感性与易感性）和株间变异对初始细菌缔合均具有显着影响（均P <0.05）。与不那么易感的患者相比，慢性成人牙周炎组显示牙龈卟啉单胞菌的关联性更高（4.2 x 10（6）对3.5 x 10（6））。同样，菌株间的差异也很显着，菌株Pg 4和5代表最少和最佳的结合细菌（Pg 4的菌落形成单位为1.8 x 10（6），Pg 5的菌落形成单位为9 x 10（6））。结论：这些结果表明，牙周炎易感性受口袋上皮个体间差异（允许牙龈假单胞菌更多的粘附）或患者感染的菌株类型（物种内粘附能力的差异）的影响。

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