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首页> 外文期刊>Clinics in dermatology >Sarcoidosis and malignancy.
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Sarcoidosis and malignancy.

机译：结节病和恶性肿瘤。

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Malignancy in patients with sarcoidosis occurs in 3 settings. The first setting relates to patients with hematologic malignancies. It includes the sarcoidosis-lymphoma syndrome, which refers to the development of lymphoma at least 1 to 2 years after the diagnosis of sarcoidosis. It also includes patients with sarcoidosis who develop other hematologic malignancies. In addition, this subset of individuals includes patients with cancer and hematologic malignancies who subsequently develop sarcoidosis. The second setting consists of patients with sarcoidosis who develop solid tumors and oncologic patients in whom sarcoidosis subsequently appears; in addition to melanoma and nonmelanoma skin cancer, the neoplasms most commonly associated involve the cervix, liver, lung, testicles, and uterus. The third setting of malignancy-related sarcoidosis occurs when sarcoidosis presents as a paraneoplastic syndrome for the associated cancer, specifically when the discovery of cancer is concurrent with or within 1 yearof the diagnosis of sarcoidosis or vis-a-vis. Antineoplastic treatment of either the hematologic malignancy or the solid tumor has also been observed to either induce the initial onset or flare the activity of sarcoidosis. Malignancy can also be associated with the occurrence of sarcoid reactions that typically are restricted to the regional lymph nodes or the visceral organ of tumor origin; rarely, the sarcoid reaction can also be observed in the skin or is only limited to the skin.
机译：结节病患者的恶性肿瘤在3种情况下发生。第一种情况涉及血液系统恶性肿瘤患者。它包括结节病-淋巴瘤综合征，是指结节病诊断后至少1-2年发展为淋巴瘤。它还包括结节病患者，其发展为其他血液系统恶性肿瘤。另外，该个体子集包括患有癌症和血液系统恶性肿瘤的患者，这些患者随后发展为结节病。第二种情况是结节病患者发展为实体瘤，肿瘤患者随后出现结节病。除了黑色素瘤和非黑色素瘤皮肤癌外，最常见的肿瘤还包括子宫颈癌，肝癌，肺癌，睾丸癌和子宫癌。当结节病表现为相关癌症的副肿瘤综合症时，特别是当发现结节病或相对于结节病同时或在一年之内发现癌症时，就会发生恶性肿瘤结节病的第三种情况。还已观察到血液恶性肿瘤或实体瘤的抗肿瘤治疗可诱导结节病的发作或发作。恶性肿瘤也可能与结节病反应的发生有关，结节病反应通常仅限于区域淋巴结或肿瘤起源的内脏器官。很少会在皮肤上观察到类肌瘤反应，或仅局限于皮肤。

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