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首页> 外文期刊>Clinics in dermatology >Seborrheic dermatitis: Etiology, risk factors, and treatments: Facts and controversies
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Seborrheic dermatitis: Etiology, risk factors, and treatments: Facts and controversies

机译：脂溢性皮炎：病因，危险因素和治疗方法：事实和争议

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Seborrheic dermatitis (SD) is a common skin condition seen frequently in clinical practice. The use of varying terms such as sebopsoriasis, seborrheic dermatitis, seborrheic eczema, dandruff, and pityriasis capitis reflects the complex nature of this condition. Despite its frequency, much controversy remains regarding the pathogenesis of SD. This controversy extends to its classification in the spectrum of cutaneous diseases, having being classified as a form of dermatitis, a fungal disease, or an inflammatory disease, closely related with psoriasis. Some have postulated that SD is caused by Malassezia yeasts, based on the observation of their presence in affected skin and the therapeutic response to antifungal agents. Others have proposed that Malassezia is incidental to a primary inflammatory dermatosis that resulted in increased cell turnover, scaling, and inflammation in the epidermis, similar to psoriasis. The presence of host susceptibility factors, permitting the transition of M furfur to its pathogenic form, may be associated with immune response and inflammation. Metabolites produced by Malassezia species, including oleic acid, malssezin, and indole-3-carbaldehyde, have been implicated. SD also has been traditionally considered to be a form of dermatitis based on the presence of Malassezia in healthy skin, the absence the pathogenic mycelial form of Malassezia yeasts in SD, and its chronic course. As a result, proposed treatments vary, ranging from topical corticosteroids to topical antifungals and antimicrobial peptides.
机译：脂溢性皮炎（SD）是临床实践中常见的常见皮肤病。使用诸如脂溢性皮疹，脂溢性皮炎，脂溢性湿疹，头皮屑和牛皮癣的各种术语之类的词反映了这种情况的复杂性。尽管其发病率高，但关于SD的发病机理仍存在许多争议。该争议已扩展至其在皮肤疾病范围内的分类，已被分类为与牛皮癣密切相关的一种皮炎，真菌病或炎性疾病。根据观察到它们在受影响的皮肤中的存在以及对抗真菌剂的治疗反应，有人推测SD是由马拉色酵母引起的。其他人提出，马拉色菌病与原发性炎症性皮肤病有关，导致皮肤更新，鳞屑增多和表皮发炎，类似于牛皮癣。宿主易感性因子的存在，允许糠醛M转化为其致病性形式，可能与免疫反应和炎症有关。已经暗示了由马拉色菌属物种产生的代谢产物，包括油酸，马尔济辛和吲哚-3-甲醛。基于健康皮肤中马拉色菌的存在，SD中马拉色菌酵母菌的病原菌丝形式及其慢性病程的存在，传统上SD也被认为是一种皮炎。结果，提议的治疗方法有所不同，范围从局部皮质类固醇到局部抗真菌药和抗菌肽。

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