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History of chemotherapy of leprosy

机译：麻风化学疗法的历史

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Chemotherapy of leprosy over the past 70 years has passed through several phases, from sulfones, to clofazimine, and to highly bactericidal drugs like rifampicin. The use particularly of the more potent drugs in effective combinations and the development of standard multidrug therapy regimens have made a huge difference in the successful treatment of leprosy as well as in reducing tremendously the prevalence of leprosy globally. A major contributing factor to development of better drugs and drug combinations has been the introduction of the mouse footpad model to evaluate the in vivo activity of drugs against Mycobacterium leprae. The World Health Organization has recommended multidrug therapy, which has been used to treat more than 15 million patients in the last 30 years and has set an excellent record with regard to its very high rate of cure, very low occurrence of relapse, and very rare occurrence of drug resistance. (C) 2016 Elsevier Inc. All rights reserved.
机译：在过去的70年中，麻风病的化学治疗经历了多个阶段，从砜到氯法齐明，再到诸如利福平的高度杀菌药物。特别是在有效组合中使用更有效的药物以及标准多药治疗方案的发展，在成功治疗麻风病以及极大地降低全球麻风病发病率方面都产生了巨大的差异。开发更好的药物和药物组合的主要促成因素是引入小鼠足垫模型以评估药物对抗麻风分枝杆菌的体内活性。世界卫生组织推荐了多种药物疗法，该疗法在过去30年中已用于治疗超过1500万患者，并以其极高的治愈率，极低的复发率以及非常罕见的治疗方法创下了卓越的记录。发生耐药性。 （C）2016 Elsevier Inc.保留所有权利。

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