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首页> 外文期刊>Journal of Physiology and Biochemistry >Antiatherogenic and antitumoral properties of Opuntia cladodes: inhibition of low density lipoprotein oxidation by vascular cells, and protection against the cytotoxicity of lipid oxidation product 4-hydroxynonenal in a colorectal cancer cellular model
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Antiatherogenic and antitumoral properties of Opuntia cladodes: inhibition of low density lipoprotein oxidation by vascular cells, and protection against the cytotoxicity of lipid oxidation product 4-hydroxynonenal in a colorectal cancer cellular model

机译：仙人掌的抗动脉粥样硬化和抗肿瘤特性：在大肠癌细胞模型中抑制血管细胞低密度脂蛋白氧化，并抵抗脂质氧化产物4-hydroxynonenal的细胞毒性

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Opuntia species have been used for thousands of years as a folk medicine in the treatment of diseases. However, the components and protective mechanisms are still unclear. We make the hypothesis that Opuntia species may protect the development of oxidative stress-associated diseases, such as atherosclerosis or colon cancer, via their antioxidant properties. We investigated the protective effect of Opuntia cladode powder against the oxidation of low-density lipoprotein (LDL) evoked by vascular endothelial cells, an important risk factor for atherosclerosis development, and the toxicity of 4-hydroxynonenal (a major lipid peroxidation product) on normal (Apc +/+) and preneoplastic (Apc min/+) immortalized epithelial colon cells. Various Opuntia species classified according to their degree of domestication, from the wildest (Opuntia streptacantha, Opuntia hyptiacantha, Opuntia megacantha), medium (Opuntia albicarpa), to the most domesticated (Opuntia ficus-indica) were tested. Cladode powders prepared from these Opuntia species significantly inhibited LDL oxidation induced by incubation with murine endothelial cells and the subsequent foam cell formation of RAW 264.7 murine macrophages and cytotoxicity on murine endothelial cells. Moreover, Opuntia cladode powder blocked the promotion of colon cancer development on an in vitro model of colonocytes. It may be noted that the phenolic acid and flavonoids content, the antioxidant capacity, and the protective effect were relatively similar in all the cladode powders from wild (O. streptacantha) and domesticated Opuntia. Altogether, these data confirm the therapeutic potential of Opuntia cladodes in diseases associated with oxidative stress.
机译：仙人掌物种作为一种用于疾病治疗的民间药物已有数千年的历史了。但是，其组成和保护机制仍不清楚。我们做出这样的假设：仙人掌物种可以通过其抗氧化特性来保护与氧化应激相关的疾病的发展，例如动脉粥样硬化或结肠癌。我们研究了仙人掌花粉对血管内皮细胞引起的低密度脂蛋白（LDL）氧化，动脉粥样硬化发展的重要危险因素以及4-羟基壬烯醛（一种主要的脂质过氧化产物）的毒性的保护作用。 （Apc + / +）和肿瘤前（Apc min / +）永生化的上皮结肠细胞。测试了根据其驯化程度分类的各种仙人掌种类，从最野生的（Opuntia streptacantha，Opuntia hyptiacantha，Opuntia megacantha），中等的（Opuntia albicarpa）到最驯化的（Opuntia ficus-indica）。由这些仙人掌属物种制备的克拉德粉显着抑制了与鼠内皮细胞孵育以及随后的RAW 264.7鼠巨噬细胞的泡沫细胞形成以及对鼠内皮细胞的细胞毒性而诱导的LDL氧化。此外，仙人掌金粉在结肠细胞的体外模型上阻止了结肠癌的发展。可以注意到，野生（O. streptacantha）和驯化的仙人掌中的所有复合粉末中的酚酸和类黄酮含量，抗氧化能力和保护作用都相对相似。总而言之，这些数据证实了仙人掌枝在与氧化应激有关的疾病中的治疗潜力。

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