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首页> 外文期刊>Journal of pesticide science >Indoxacarb interaction alters immunotoxic and genotoxic potential of endotoxin
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Indoxacarb interaction alters immunotoxic and genotoxic potential of endotoxin

机译：茚虫威相互作用可改变内毒素的免疫毒性和遗传毒性

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Indoxacarb is commonly used to effectively control pests, cockroaches, termites, fleas, and houseflies. Although the toxicological profile of indoxacarb had already been well characterized, we examined the possible toxicological interaction with indoxacarb and endotoxin. Male Swiss albino mice aged 8-10 weeks were orally administered indoxacarb dissolved in groundnut oil at 4 mg/ kg/day and 2 mg/kg/day for 90 days. On day 91, five animals from each group were challenged with lipopolysaccharides (LPS) at 80 mu g/mouse, administered intranasally. Indoxacarb at 4 mg/kg significantly decreased Total leukocyte count, lymphocytopenia, and neutrophilia. Both doses of indoxacarb combined with LPS resulted in significant lymphocytopenia. Indoxacarb did not produce DNA damage in comet assay, but when combined with LPS, it resulted in a significant increase in tail length, tail moment, and olive moment. The data indicate that indoxacarb at 4 mg/kg administered orally for 90 days induced immune-response change. Further, both doses of indoxacarb, when combined with LPS, accelerate immunotoxicity and endotoxin-induced DNA damage. (C) Pesticide Science Society of Japan
机译：茚虫威通常用于有效控制害虫，蟑螂，白蚁，跳蚤和家蝇。尽管已对茚虫威的毒理学特征进行了很好的表征，但我们研究了与茚虫威和内毒素的可能的毒理学相互作用。对雄性8-10周的瑞士白化病小鼠口服吲哚威威溶于花生油中的剂量为4 mg / kg / day和2 mg / kg / day，共90天。在第91天，通过鼻内给药以每只小鼠80μg的脂多糖（LPS）攻击每组的五只动物。茚虫威4 mg / kg显着降低总白细胞计数，淋巴细胞减少和中性粒细胞减少。两种剂量的茚虫威与LPS组合均导致明显的淋巴细胞减少。茚虫威在彗星试验中不会产生DNA损伤，但与LPS结合使用时，会导致尾长，尾矩和橄榄矩显着增加。数据表明，口服90毫克4毫克/千克的茚虫威可诱导免疫反应改变。此外，两种剂量的茚虫威都与LPS结合使用时，会加速免疫毒性和内毒素诱导的DNA损伤。 （C）日本农药学会

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