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Emerging systemic fungal infections

机译:新兴的全身性真菌感染

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Systemic mycoses are a heterogeneous group of infections caused by different species of fungi that mainly affect individuals with primary or secondary alterations of immunity. In recent years, there has been an increase in the incidence of infections related to migration, AIDS, and other causes of immunosuppression, such as solid organ and bone marrow transplantation; oncological, hematological, and autoimmune diseases; and the use of new drugs. In this paper, we outline the microbiological and epidemiological characteristics of 3 fungi: Aspergillus spp, Fusarium spp, and Penicillium spp. We describe the clinical manifestations of disease with emphasis on those that should alert the dermatologist to make an early diagnosis. We detail the various tools for early diagnosis, prevention, and the epidemiology of different antifungals available for treatment and their mechanism of action and therapeutic efficacy.
机译:全身性真菌病是由不同种类的真菌引起的一组异质感染,主要影响具有免疫原发性或继发性改变的个体。近年来,与迁移,艾滋病和其他免疫抑制原因有关的感染发生率增加,例如实体器官和骨髓移植。肿瘤,血液和自身免疫性疾病;以及使用新药。在本文中,我们概述了三种真菌的微生物学和流行病学特征:曲霉菌,镰刀菌和青霉菌。我们描述疾病的临床表现,重点放在那些应提醒皮肤科医生作出早期诊断的表现上。我们详细介绍了用于早期诊断,预防以及可用于治疗的不同抗真菌剂的流行病学的各种工具,以及它们的作用机理和疗效。

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