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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Dielectric response of biconcave erythrocyte membranes to D- and L-glucose
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Dielectric response of biconcave erythrocyte membranes to D- and L-glucose

机译：双凹红细胞膜对D和L葡萄糖的介电响应

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摘要

In this paper, we report on the influence of D- and L-glucose on the dielectric properties of native shaped ( biconcave) human erythrocytes using time domain dielectric spectroscopy. The dielectric spectra of biconcave cells were analysed using a modified form of the model originally reported for spheroid particle suspensions (Asami and Yonezawa 1995 Biochim. Biophys. Acta. 1245 317-24) The observed increase in the specific membrane capacitance of the biconcave erythrocytes was correlated with an increase in the concentration of D-glucose. In contrast, no associated correlation was found to changes in the membrane capacitance with increasing concentrations of L-glucose. A similar analysis of the dielectric response of osmotically swollen erythrocytes to changes in D-glucose concentration revealed a significantly different calculated specific cell membrane capacitance at elevated (> 12 mM) D-glucose concentrations. The paper outlines and discusses the possible biochemical mechanisms that could be responsible for the measured dielectric properties of the erythrocyte membrane capacitances.
机译：在本文中，我们使用时域介电谱报告了D-和L-葡萄糖对天然形状（双凹面）人红细胞介电特性的影响。使用最初报导的球体颗粒悬浮液模型的修改形式分析了双凹细胞的介电谱（Asami和Yonezawa 1995 Biochim.Biophys.Acta.1245 317-24）。观察到的双凹红细胞比膜电容的增加为与D-葡萄糖浓度增加有关。相反，未发现随着L-葡萄糖浓度的增加膜电容的变化具有相关性。渗透性红细胞对D-葡萄糖浓度变化的介电反应的类似分析显示，在D-葡萄糖浓度升高（> 12 mM）时，计算出的比细胞膜电容存在显着差异。本文概述并讨论了可能的生物化学机制，这些机制可能是所测量的红细胞膜电容的介电特性的原因。

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