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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >AC electrokinetic manipulation of DNA
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AC electrokinetic manipulation of DNA

机译：DNA的交流电动控制

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摘要

The controlled manipulation of molecules is a crucial prerequisite for the emerging field of molecular nanotechnology. AC electrokinetics provide a powerful mechanism for both positioning and inducing conformational changes in molecules. In this paper, we investigate the elongation of fluorescently-labelled DNA strands, which are covalently tethered by one end to gold microelectrodes arranged in an opposing-finger geometry, when exposed to strong ac electric fields. We found that the elongation of the DNA molecules is restricted by the geometry of the gap, and that the observed contour of the elongated DNA molecules coincides with the electric field line pattern. Further, we discuss a potential elongation mechanism and provide evidence that the major contribution to the elongation originates from the ac electrokinetic torque, which is supplemented by a small bias force provided by the electric-field-induced fluid flow.
机译：分子的受控操纵是分子纳米技术新兴领域的关键先决条件。交流电动力学为分子定位和诱导构象变化提供了强大的机制。在本文中，我们研究了荧光标记的DNA链的延伸，当暴露于强交流电场时，荧光标记的DNA链的一端被共价束缚在以对指几何形状排列的金微电极上。我们发现，DNA分子的延伸受到间隙几何形状的限制，并且观察到的细长DNA分子的轮廓与电场线图重合。此外，我们讨论了一种潜在的伸长机制，并提供了证据表明，伸长的主要贡献源于交流电动势，而交流电动势由电场感应的流体流提供的较小偏压力所补充。

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