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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Growth and dissolution of apatite precipitates formed in vivo on the surface of a bioactive glass coating film and its relevance to bioactivity
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Growth and dissolution of apatite precipitates formed in vivo on the surface of a bioactive glass coating film and its relevance to bioactivity

机译：在生物活性玻璃涂膜表面上体内形成的磷灰石沉淀物的生长和溶解及其与生物活性的关系

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Development of bioactive glasses for use as a coating on Ti6Al4V prostheses requires a better understanding of reactions at the bone/bioactive glass interface. Indeed, the bioactive glasses bond to bone through physico-chemical reactions. In vivo, an apatite rich layer is built up on top of a pure silica rich layer at the bioactive glass periphery. In this paper, we have studied Ti6Al4V cylinders coated with a bioactive glass and implanted in sheep femora for two, three and six months. At each time period, the samples were analysed with scanning transmission electron microscopy coupled with energy dispersive x-ray spectroscopy. In vivo, the bioactive glass dissolution led to the formation on its surface of spherical particles with different sizes. The distributions of Si, Al, Ca, P and Mg concentrations across the particles reveal precipitation of apatite with the incorporation of magnesium. Apatite precipitation is governed by diffusion through an Si layer and occurs under specific supersaturation conditions. Measurements of supersaturation for Ca and P demonstrate that the largest precipitates grow and the smallest dissolve. These results allow us to study the growth and dissolution rate of the apatite precipitates and their relevance to bioactivity. Particles with a radius twice the average radius ((R)) grow the fastest and, if the radius increases, the rate of,growth decreases. Before three months, the growth of apatite precipitates ((R) Fs 1 mum) leads to the growth of a Ca-P interfacial layer. After three months, (R) is of the order of 0.5 mum, and the majority of the apatite layer dissolves. The effects of aluminium and magnesium on apatite generation are also studied. [References: 21]
机译：开发用作Ti6Al4V假体涂层的生物活性玻璃需要更好地了解骨骼/生物活性玻璃界面的反应。实际上，生物活性玻璃通过理化反应与骨骼结合。在体内，在生物活性玻璃外围的纯二氧化硅富集层之上建立了富含磷灰石的层。在本文中，我们研究了涂有生物活性玻璃并植入羊股骨的Ti6Al4V钢瓶两个，三个和六个月。在每个时间段，通过扫描透射电子显微镜和能量色散X射线光谱法对样品进行分析。在体内，生物活性玻璃的溶解导致在其表面上形成大小不同的球形颗粒。 Si，Al，Ca，P和Mg浓度在整个颗粒中的分布表明磷灰石的沉淀与镁的结合。磷灰石沉淀受通过硅层的扩散控制，并在特定的过饱和条件下发生。对Ca和P的过饱和度的测量表明，最大的沉淀物生长而最小的溶解度。这些结果使我们能够研究磷灰石沉淀物的生长和溶解速率及其与生物活性的关系。半径两倍于平均半径（R）的粒子生长最快，如果半径增加，则增长率会降低。在三个月之前，磷灰石沉淀物的生长（（Rs Fs 1 mum）导致Ca-P界面层的生长。三个月后，（R）约为0.5微米，大部分磷灰石层溶解。还研究了铝和镁对磷灰石生成的影响。 [参考：21]

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