The objective of this study was to more clearly characterize the immunomodulatory effects of swainsonine and an Ipomoea carnea aqueous fraction using two different mouse strains: Swiss outbred mice and C57BL/6 inbred mice. The swainsonine is the main toxic principle found in the Ipomoea carnea a poisonous plant native from Brazil and other tropical countries. Many studies have shown that swainsonine promotes biological response modifications in different cell lines, such as increased murine splenic NK lymphocyte activity, improvement of peritoneal macrophage activity and macrophage cytotoxicity against tumor cells. In addition, it is suggested that swainsonine stimulates bone marrow cell proliferation in inbred mice. Therefore, we evaluated in this study the immunomodulatory effects of swainsonine and I,
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