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首页> 外文期刊>Journal of pharmacology & toxicology. >Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats
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Evaluation of Safety and Immunotoxicity of Immunol, A Polyherbal Formulation in Rats

机译：一种大鼠多草药制剂Immunol的安全性和免疫毒性评估

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摘要

Immunol, a polyherbal formulation was evaluated for its safety and effect on the immune system of rats. The rats were administered a single oral dose of 20 mL kg~(-1) b.wt. while others were given repeated doses of 1, 5 and 10 mL kg~(-1) b.wt., orally for 28 days. Immunol treatment did not elicit any abnormalities on the body weight gain, food consumption, neurological assessment, hematology and clinical chemistry parameters, organ weights, gross organ pathology and histopathology and humoral immunity, but it enhanced the cell mediated immunity. It was concluded that Immunol was safe at single oral dose of 20 mL kg~(-1) b.wt. and repeated dose of 10 mL kg~(-1) b.wt. in rats for 28 days.
机译：评估了多草药制剂Immunol的安全性和对大鼠免疫系统的影响。给大鼠单次口服剂量为20 mL kg〜（-1）b.wt.其余人则口服28天内分别重复服用1、5和10 mL kg〜（-1）b.wt. wt。的剂量。免疫治疗未引起体重增加，食物消耗，神经学评估，血液学和临床化学参数，器官重量，大体器官病理及组织病理学和体液免疫方面的任何异常，但增强了细胞介导的免疫。结论：单次口服剂量为20 mL kg〜（-1）b.wt.，Immunol是安全的。重复剂量为10 mL kg〜（-1）b.wt.在大鼠中持续28天。

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