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首页> 外文期刊>Journal of pharmacology & toxicology. >Anti Inflammatory, Antinociceptive and Central Nervous System Depressant Activities of Marine Bacterial Extracts
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Anti Inflammatory, Antinociceptive and Central Nervous System Depressant Activities of Marine Bacterial Extracts

机译：海洋细菌提取物的抗炎，镇痛和中枢神经系统抑制活性

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摘要

The main objective of this study is to isolate the bacterial strains which are producing biomedicinally relevant secondary metabolites. To achieve this, the ethyl acetate extracts of four marine bacterial strains BR1, PC4, EMI 3 and EM14 which were isolated from Balanus amphitrite (barnacle), Polyclinumconstellation (ascidian) and Enteromorpha compressa (Seaweed), respectively subjected to study the anti inflammatory, analgesic and central nervous system depressant activities. Anti inflammatory activity was studied by carragennan induced rat paw edema model. Though the results were significant (p<0.05) for all the four bacterial extracts the more effective anti-inflammatory activity was exhibitedbyEM13 and EM14 (range between 20-59% of inhibition).
机译：这项研究的主要目的是分离产生生物医学相关次生代谢产物的细菌菌株。为了实现这一目标，分别从Balanus amphitrite（藤壶），Polyclinum Constellation（海鞘）和Enteromorpha compressa（海藻）分离的四种海洋细菌菌株BR1，PC4，EMI 3和EM14的乙酸乙酯提取物进行了抗炎研究，镇痛和中枢神经系统抑制活性。通过卡拉格南诱导的大鼠爪水肿模型研究了抗炎活性。尽管所有四种细菌提取物的结果均显着（p <0.05），但EM13和EM14表现出更有效的抗炎活性（抑制作用在20-59％之间）。

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