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首页> 外文期刊>Journal of pharmacology & toxicology. >Anti-Angiogenic and Anti Oxidant Properties of Orthosiphon stamineus Benth. Methanolic Leaves Extract
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Anti-Angiogenic and Anti Oxidant Properties of Orthosiphon stamineus Benth. Methanolic Leaves Extract

机译：Orthosiphon stamineus Benth的抗血管生成和抗氧化性能。甲醇叶提取物

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摘要

Angiogenesis is a process by which new blood vessels are formed from the preexisting blood vessel. Orthosiphon stamineus Benth. OS has been used as a medicinal herb for many centuries. Due to the presence of high level of antioxidants and phenolic content compounds in OS and the effect of anti-oxidants and phenolic compounds being anti-angiogenic, the perturbation of new blood vessels ability of OS was tested. Dry powdered leaves of the OS plant were extracted with Petroleum Ether (PE), chloroform (CE), methanol (ME) and water (WE) by using sequential cold maceration method. The ME of OS has the highest anti-angiogenic activity (93.28+-1.24%) in the rat aortic assay followed by CE (85.55+-1.64%), PE (51.54+-4.12%) and WE (50.22+-1.23%) in descending order of reactivity. The methanol extract was also found to have potent antioxidant activity in the 1, l-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. The IC_50 value was measured to be 0.286 mg mL~-1.
机译：血管生成是从先前存在的血管形成新血管的过程。 Orthosiphon stamineus Benth。 OS已经被用作草药已有很多世纪了。由于OS中存在高水平的抗氧化剂和酚类含量化合物，并且抗氧化剂和酚类化合物具有抗血管生成作用，因此测试了OS对新血管能力的扰动。通过顺序冷浸法，用石油醚（PE），氯仿（CE），甲醇（ME）和水（WE）提取OS植物的干粉叶。 OS的ME在大鼠主动脉分析中具有最高的抗血管生成活性（93.28 + -1.24％），其次是CE（85.55 + -1.64％），PE（51.54 + -4.12％）和WE（50.22 + -1.23％） ）以反应性降序排列。在1，l-二苯基-2-吡啶并肼基（DPPH）自由基清除活性试验中，还发现甲醇提取物具有有效的抗氧化活性。 IC_50值经测量为0.286 mg mL〜-1。

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