• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of pharmacology & toxicology. >In vitro Toxicity of Multi Wall Carbon Nanoparticles on Hep G 32 Liver Cell Lines
【24h】

In vitro Toxicity of Multi Wall Carbon Nanoparticles on Hep G 32 Liver Cell Lines

机译：多壁碳纳米颗粒对Hep G 32肝细胞系的体外毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present study was to evaluate the in vitro toxicity of two Multi Wall Carbon Nanotubes (MWCNT) on human hepatocytes (Hep G 32 cell lines). The toxic effects of carbon nanoparticles were analyzed after 24 h of incubation with different cell lines using MTT assay and also estimated the levels of Lactate Dehydrogenase (LDH) (that is leakaged into the media). The results of the LDH estimation demonstrated that exposure of multi wall carbon nanotubes to hepatocytes (Hep G 32) for 24 h resulted in concentration-dependent increase in LDH leakage and exhibited a significant (p<0.05) cytotoxicity at a concentration range of 3-50 jig mL~-1. The TC_50 or IC_50 values (toxic concentration 50 i.e., concentration of particles inducing 50% cell mortality) of two nanoparticles (1) were found in the range of 36.99-37.15 mug mL~-1, (2) were less than that of quartz (known toxic agent, 39.85 mug mL~-1), indicating their cytotoxicity of carbon nanoparticles.
机译：本研究的目的是评估两个多壁碳纳米管（MWCNT）对人肝细胞（Hep G 32细胞系）的体外毒性。使用MTT分析法在与不同细胞系孵育24小时后，分析了碳纳米颗粒的毒性作用，并估算了乳酸脱氢酶（LDH）的水平（泄漏到培养基中）。 LDH估计的结果表明，多壁碳纳米管暴露于肝细胞（Hep G 32）24小时会导致LDH泄漏浓度依赖性增加，并且在3浓度范围内表现出显着的（p <0.05）细胞毒性。 50毫升〜-1发现两个纳米颗粒（1）的TC_50或IC_50值（毒性浓度50，即诱导50％细胞死亡的颗粒浓度）在36.99-37.15马克杯mL〜-1范围内，（2）小于石英的（已知的有毒物质39.85毫升/毫升），表明它们对碳纳米颗粒的细胞毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号