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首页> 外文期刊>Journal of pharmacology & toxicology. >Reduction in Platelet Aggregation (in vitro) by Diallyl Sulphide in Female Participants with Type 2 Diabetes Mellitus
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Reduction in Platelet Aggregation (in vitro) by Diallyl Sulphide in Female Participants with Type 2 Diabetes Mellitus

机译：二烯丙基硫化物可降低女性2型糖尿病患者的血小板聚集（体外）。

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摘要

Diallyl sulphide an active principle of garlic has been shown to have many medicinal properties. Thus present study is undertaken to see the effect of diallyl sulphide on platelet aggregation in women participants with type 2 diabetes mellitus. Women participants (18) with type 2 diabetes mellitus with >2 years duration formed the study group. The body mass index of the study group was 26+-3.4 kg m~2 and age was 47+-8.1 years. Platelet aggregation induced by adenosine diphosphate at 10 and 20 muM concentration was measured in platelet rich plasma. The effect of diallyl sulphide (2.2 mug) on platelet aggregation was seen after 1 min of incubation with platelet rich plasma. The women participants were divided into two groups (fast responders for adenosine diphosphate induced aggregation >5.0% slow responders aggregation <5.0%) based on maximal aggregation percentage. The participants had high abdominal circumference (102+-9.4) and were hypertensive. Glucose (162.5+-47.18) and glycosylated hemoglobin levels (11.7+-2.82) suggest lack of metabolic control. The triglycerides levels (185+-58.53) were also high. The platelet aggregation with adenosine diphosphate showed variation (10 muM adenosine diphosphate 2.0-81.0% and 20 muM adenosine diphosphate 9.0-93.0%) in fast responders group. The reduction in platelet aggregation with diallyl sulphide also varied with the participants. The relative reduction of adenosine diphosphate induced aggregation with aspirin ranged from 1.0-65.0%. The fibrinogen levels were in normal range. There was reduction in adenosine induced platelet aggregation by diallyl sulphide. The relative reduction in platelet aggregation by diallyl sulphide as compared to aspirin was higher in four participants in fast responder participants. The data unequivocally demonstrated the platelet aggregation inhibition properties of diallyl sulphide.
机译：二烯丙基硫化物是大蒜的有效成分，已被证明具有许多药用特性。因此，本研究旨在观察二烯丙基硫化物对2型糖尿病女性参与者血小板聚集的影响。研究对象为持续时间超过2年的2型糖尿病女性参与者（18）。研究组的体重指数为26 + -3.4 kg m〜2，年龄为47 + -8.1岁。在富含血小板的血浆中测量了浓度为10和20μM的二磷酸腺苷诱导的血小板聚集。与富含血小板的血浆孵育1分钟后，观察到二烯丙基硫化物（2.2杯）对血小板聚集的影响。根据最大聚集百分比，将女性参与者分为两组（对二磷酸腺苷诱导的聚集的快速反应者> 5.0％，对于缓慢反应的聚集者<5.0％）。参与者的腹围高（102 + -9.4），并且高血压。葡萄糖（162.5 + -47.18）和糖基化血红蛋白水平（11.7 + -2.82）表明缺乏代谢控制。甘油三酸酯水平也很高（185 + -58.53）。快速反应组中血小板与二磷酸腺苷的聚集表现出差异（10μM二磷酸腺苷2.0-81.0％和20μM二磷酸腺苷9.0-93.0％）。二烯丙基硫化物使血小板凝集减少的程度因参与者而异。阿司匹林引起的二磷酸腺苷诱导的聚集的相对减少范围为1.0-65.0％。纤维蛋白原水平在正常范围内。烯丙基二硫化物减少了腺苷诱导的血小板凝集。与阿司匹林相比，二烯丙基硫化物使血小板凝集的相对减少在快速反应参与者中有四个参与者更高。数据明确证明了二烯丙基硫化物的血小板凝集抑制特性。

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