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首页> 外文期刊>Journal of pharmacology & toxicology. >Ameliorating Effect of Vitamin E on Testicular Toxicity Induced by Endosulphan in Capra hircus in vitro
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Ameliorating Effect of Vitamin E on Testicular Toxicity Induced by Endosulphan in Capra hircus in vitro

机译：维生素E对内啡肽诱导的Capra hircus睾丸毒性的改善作用。

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摘要

During the present investigation ameliorating effect of vitamin E on endosulphan induced testicular toxicity has been analyzed in Capra hircus in vitro. Vitamin E exhibited the protective role against the damage induced by endosulphan in the testicular tissue. Small pieces (approximately 1 mm3) of testicular tissue were divided into three groups (One control and two experimental groups). One experimental group was treated with 100 nmol mL~-1 endosulphan concentration and another experimental group was treated with 100 nmol mL~-1 endosulphan and supplemented with 100 mumol L~-1concentration of vitamin E (alpha-Tocopherol). Harvesting of the testicular tissue was carried out after 1, 4 and 8 h of exposure durations in vitro. Hyalinization and fragmentation was observed in the endosulphan treated group. Chromolysis was observed in spermatogonia, Sertoli cells and spermatids. As the exposure duration enhanced from 4 to 8 h there was elevation in number of pycnotic nuclei, fragmented nuclei, chromolysis of germ cells and somatic cells present in the testis. Endosulphan exposure induced the number of atretic spermatogonia from 24% in control group to 68% after 1 h, from 30 to 76% after 4 h and from 36 to 84% after 8 h of exposure duration. In the experimental group treated with endosulphan and supplemented with vitamin E there was decline in number of pycnotic nuclei, fragmented nuclei and chromolysis as compared with the endosulphan exposed group. There was decline in atretic spermatogonia from 68 to 36% at 1 h, from 76 to 44% after 4 h and from 84 to 58% after 8 h of supplementation duration.
机译：在本研究中，已在体外Capra hircus中分析了维生素E对硫磺素引起的睾丸毒性的改善作用。维生素E对睾丸组织中硫磺素引起的损伤具有保护作用。将小块睾丸组织（约1 mm3）分成三组（一个对照组和两个实验组）。一个实验组用100 nmol mL〜-1内硫醇浓度治疗，另一实验组用100 nmol mL〜-1内硫醇浓度补充100μmolL〜-1浓度的维生素E（α-生育酚）。在体外暴露时间分别为1、4和8小时后收获睾丸组织。在硫磺内酯治疗组中观察到透明质化和断裂。在精原细胞，支持细胞和精原细胞中观察到了热解。随着暴露持续时间从4小时增加到8小时，存在于睾丸中的脓性核，核碎裂，生殖细胞和体细胞的染色体裂解数量增加。暴露于内啡肽会导致闭锁性精原细胞数量从对照组的24％增至1小时后的68％，4小时后从30％增至76％和8小时后的36％至84％。与内硫丹暴露组相比，在使用硫丹进行治疗并补充维生素E的实验组中，脓性核，核碎裂和染色体溶解的数量减少了。补充1小时后，闭锁性精原细胞减少从68％降至36％，在4小时后从76％降至44％，在8小时后从84％降至58％。

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