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首页> 外文期刊>Journal of pharmacology & toxicology. >Antioxidant, Analgesic and Anti-inflammatory Activities of the Herb Eclipta prostrata
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Antioxidant, Analgesic and Anti-inflammatory Activities of the Herb Eclipta prostrata

机译：旱莲草的抗氧化，镇痛和抗炎活性

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摘要

The present study was designed to investigate the antioxidant, analgesic and anti-inflammatory potential of the methanolic extract along with its organic soluble fractions of the herb Eclipta prostrata. In addition, total phenolic and flavonoid content and total antioxidant capacity were also determined. Antioxidant potential of the extract/fractions was evaluated by DPPH (l,ldiphenyl-2-picrylhydrazyl), NO (nitric oxide) and ONOO" (peroxynitrite) scavenging assay method. Ethyl acetate fractions (EtOAc) showed highest scavenging activity in all the methods with IC_(50) value of 12.98+-0.08, 45.98+-0.07 and 14.45+-0.18 ng mLr1 for DPPH, NO and ONOO" assay method, respectively. In reducing power assay, EtOAc fraction also showed significant (p<0.001) activity. Further, the extract/fractions were studied for their analgesic (hot plate, tail immersion and acetic acid induced writhing test) and anti-inflammatory (carrageenan induced paw edema in rats) activities at a dose level of 200 and 400 mg kg"1 body weight. Among all the extract/fractions, EtOAc fraction showed a dose dependent and significant (p<0.005, p<0.05) analgesic activity in all the tested method. EtOAc fractions also reduced the paw edema considerably (86.80% inhibition after 3 h, p<0.005, p<0.05) in dose dependent manner compared to carrageenan induced rat. Altogether, these results suggest that the MeOH extract and its organic soluble fractions could be used as a potential antioxidant, analgesic and anti-inflammatory agent.
机译：本研究旨在研究甲醇提取物及其中草药旱莲草的有机可溶部分的抗氧化，止痛和抗炎潜力。另外，还测定了总酚和类黄酮含量以及总抗氧化剂容量。通过DPPH（1，ldiphenyl-2-picrylhydrazyl），NO（一氧化氮）和ONOO“（过氧亚硝酸盐）清除测定方法评估提取物/级分的抗氧化潜力。在所有方法中，乙酸乙酯馏分（EtOAc）表现出最高的清除活性对于DPPH，NO和ONOO“分析方法，IC_（50）值分别为12.98 + -0.08、45.98 + -0.07和14.45 + -0.18 ng mLr1。在还原能力测定中，EtOAc馏分也显示出显着（p <0.001）活性。此外，还研究了提取物/馏分在200和400 mg kg“ 1体重的剂量下的镇痛作用（热板，尾巴浸没和乙酸诱导的扭体试验）和抗炎作用（角叉菜胶诱导的大鼠足水肿）。在所有提取物/馏分中，EtOAc馏分在所有测试方法中均显示出剂量依赖性且显着的镇痛活性（p <0.005，p <0.05），EtOAc馏分还显着减轻了爪水肿（3 h后抑制率为86.80％，与角叉菜胶诱导的大鼠相比，p <0.005，p <0.05）呈剂量依赖性，这些结果表明，MeOH提取物及其有机可溶物可作为潜在的抗氧化剂，镇痛剂和抗炎剂。

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