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首页> 外文期刊>Journal of pharmacology & toxicology. >Evaluation of Phytochemical, Antioxidant and Hepatoprotective Activity of Tuber of Geodorum laxiflorum Griff
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Evaluation of Phytochemical, Antioxidant and Hepatoprotective Activity of Tuber of Geodorum laxiflorum Griff

机译：香菇块茎块茎的植物化学，抗氧化和保肝活性的评价

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摘要

Liver diseases are one of the major causes of mortality and morbidity in humans. Incidence and prevalence of hepatotoxicity due to drugs are increasing and is one of the main contributing factor of death. Herbs of medicinal value are being used since ancient times for the treatment of liver diseases. Orchid plants have ornamental importance but few are known for medicinal use. So, the present study was designed to investigate phytochemical, anti-oxidant and hepatoprotective property of methanolic extract of tuber of Geodorum laxiflorum. Tubers were powdered and extracted with methanol in Soxhlet apparatus to get residue (yield, 25 g, 10%). Phytochemical tests confirmed the presence of flavonoid, polyphenols, sterols and carbohydrates in methanolic extract of the tuber. Chromatographic separation was performed and two major flavonoid were isolated (yield, 25.6% of fraction IV and 31.2% of fraction V). The 50-250 jig mL"1 of extract were evaluated for antioxidant activity in DPPH model. IC_(50) value of extract was 213 (ig mLr1. In acute oral toxicity study, extract was found safe and non-toxic even in higher dose of 2000 mg kg"1 b.wt. Thirty-six healthy adult Wistar albino rats (150-200 g) of either sex were used for the investigation of in vivo hepatoprotective activity of methanolic extract. About 50, 100 and 200 mg kg""1 per oral of extract were used for hepatoprotective activity and compared with 100 mg kg"1 silymarin as standard. Methanolic extract showed prominent reduction in elevated hepatic marker enzymes and significant (p<0.001). In histopathological examination it is observed that extract has significant hepatoprotective activity. In in vitro antioxidant study, extract has shown significant free- radical inhibition activity. Phytochemical analysis of the extract has proved to have flavonoids and polyphenols. In conclusion, the MeOH extract of Geodorum laxiflorum has antioxidant and hepatoprotective activity and contain potent phytochemicals.
机译：肝病是人类死亡和发病的主要原因之一。药物引起的肝毒性的发生率和患病率正在增加，并且是死亡的主要促成因素之一。自古以来就将具有药用价值的草药用于治疗肝脏疾病。兰花植物具有观赏性，但很少用于药用。因此，本研究旨在研究Geodorum laxiflorum块茎甲醇提取物的植物化学，抗氧化和保肝性能。将块茎磨成粉末，并在索氏提取器中用甲醇萃取，得到残留物（产量，25 g，10％）。植物化学测试证实，块茎的甲醇提取物中存在类黄酮，多酚，固醇和碳水化合物。进行色谱分离，分离出两个主要的类黄酮（收率，级分IV的25.6％和级分V的31.2％）。在DPPH模型中评估了提取物的50-250 jig mL“ 1的抗氧化活性。提取物的IC_（50）值为213（ig mLr1。在急性口服毒性研究中，即使高剂量的提取物也被发现是安全且无毒的。将2000mg / kg“ 1b.wt。的三十六只健康的成年Wistar白化病大鼠（150-200g），两性用于研究甲醇提取物的体内肝保护活性。约50、100和200mg / kg”。 “每口服提取物1个用于肝保护活性，并与100 mg kg” 1水飞蓟素进行比较。甲醇提取物显示肝标志物酶升高显着降低，且显着（p <0.001）。在组织病理学检查中观察到该提取物具有在体外抗氧化剂研究中，提取物表现出显着的自由基抑制活性，提取物的植物化学分析证明其具有黄酮类化合物和多酚类化合物;总而言之，Geodorum laxiflorum的MeOH提取物具有抗衰老作用。具有抗氧化剂和保肝活性，并含有有效的植物化学物质。

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