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首页> 外文期刊>Journal of pharmacology & toxicology. >Evaluation of Anti-asthmatic Activities of Ixora coccinea Linn (Rubiaceae)
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Evaluation of Anti-asthmatic Activities of Ixora coccinea Linn (Rubiaceae)

机译：墨西哥洋蓟（Ixora coccinea Linn）的抗哮喘活性评价

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摘要

Ixora coccinea L. (Rubiaceae) possess anti-inflammatory and antitussive properties. It is traditionally used for various respiratory ailments including catarrhal bronchitis cough and asthma. In the present study we investigated anti-asthmatic properties of an hydroalcoholic leaf extract of I. coccinea in an ovalbumin (OVA)-induced asthmatic rat model. We also evaluated the anti-allergic property of the extract by Abdominal Wall (AW) method and histamine-induced cutaneous reaction. Rats were sensitized with intraperitoneal (i.p.) ovalbumin and challenged by OVA intranasally to induce chronic airway inflammation. Randomized treatment groups of sensitized rats received I coccinea extract or distilled water. I coccinea extract at doses of 1000 and 1500 mg kg"1 suppressed eosinophilia and significantly inhibited AHR in rat with OVA-induced asthma. Based on lung histopathological study using hematoxylin and eosin I coccinea reduced inflammatory cell infiltration and repaired epithelial cells damaged. In addition the extract at the same doses significantly decreased the diameter of the blue spot (18 and 55%, respectively) compared with the controls and inhibited the skin reactions induced by histamine (23.55 and 53.36%, respectively). In conclusion our results provide evidence that I coccinea has anti-asthmatic properties and then can support its use in folk medicine to treat asthma.
机译：Ixora coccinea L.（Rubiaceae）具有消炎和镇咳作用。传统上，它用于各种呼吸系统疾病，包括卡他性支气管炎咳嗽和哮喘。在本研究中，我们研究了卵白蛋白（OVA）诱发的哮喘大鼠模型中球菌I. coccinea的水醇叶提取物的抗哮喘特性。我们还通过腹壁（AW）和组胺引起的皮肤反应评估了提取物的抗过敏特性。用腹膜内（i.p.）卵清蛋白致敏大鼠，并经鼻内OVA攻击以诱导慢性气道炎症。致敏大鼠的随机治疗组接受I球蛋白提取物或蒸馏水。 I西卡因提取物在1000和1500 mg kg“ 1的剂量下可抑制OVA诱发的哮喘大鼠的嗜酸性粒细胞增多并显着抑制AHR。基于苏木精和伊红的肺组织病理学研究，西卡因减少了炎症细胞浸润并修复了上皮细胞受损。与对照组相比，相同剂量的提取物显着降低了蓝点的直径（分别为18和55％），并抑制了由组胺引起的皮肤反应（分别为23.55和53.36％）。我的球花具有抗哮喘特性，因此可以支持其在民间医学中用于治疗哮喘。

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