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首页> 外文期刊>Journal of pharmacology & toxicology. >Carbon Tetrachloride-induced Hepatotoxicity and Nephrotoxicity in Rats: Protective Role of Vitamin C
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Carbon Tetrachloride-induced Hepatotoxicity and Nephrotoxicity in Rats: Protective Role of Vitamin C

机译：四氯化碳诱导的大鼠肝毒性和肾毒性：维生素C的保护作用

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摘要

Glutathione plays an important role in the detoxification of most toxic agents. This study was planned to investigate the protective effect of vitamin C on chronic and acute models of carbon tetrachloride (CCl_4)-induced oxidative stress and changes of the glutathione concentration (GSH) in the liver and kidney of Wistar rats. The administration of vitamin C (Vit. C) to the rats (100 mg/1 kg) with intraperitoneal injection of CC1_4 at dose level of 0.2 mL kg~-1 (twice a week for 3 months) or 1 mL kg~-1 (single dose) significantly reduced the elevated plasma levels of aminotransferases, alkaline phosphatase, blood hydroperoxide, malondialdehyde in liver and kidney and blood creatinine. Vit. C antagonized the decrease of GSH level caused by CC1_4. In CC1_4 (chronic dose) + Vit. C group, plasma cholesterol and triglycerides levels were significantly decreased, while high density lipoprotein and protein concentrations were significantly increased, when compared to CC1_4 group. The treatment of rats with CC1_4 as a single dose (1 mL kg~-1) has no significant influence on lipids. Plasma urea and uric acid levels of CCl_4+Vit. C group were significantly increased as compared to CCl_4 group. These results showed that vitamin C had a protective effect on hepatotoxicity and renal toxicity caused by CCl_4 induced oxidative stress via its antioxidative property, reducing the lipid peroxidation and normalizing the glutathione level with improved the alterations in the biochemical markers. Moreover, Vit. C showed hypolipidemic effect in CCl_4-treated rats.
机译：谷胱甘肽在大多数有毒物质的排毒中起着重要作用。计划进行这项研究，以研究维生素C对四氯化碳（CCl_4）诱导的氧化应激的慢性和急性模型以及Wistar大鼠肝脏和肾脏中谷胱甘肽浓度（GSH）变化的保护作用。腹膜内注射CC1_4，以0.2 mL kg〜-1（每周两次，连续3个月）或1 mL kg〜-1的剂量向大鼠（100 mg / 1 kg）施用维生素C（维生素C） （单剂量）可显着降低血浆中氨基转移酶，碱性磷酸酶，血液中的氢过氧化物，肝肾和肾脏中的丙二醛和血肌酐水平。维特C对抗由CC1_4引起的GSH水平降低。以CC1_4（慢性剂量）+ Vit。与CC1_4组相比，C组的血浆胆固醇和甘油三酯水平显着降低，而高密度脂蛋白和蛋白浓度显着升高。单剂量CC1_4（1 mL kg〜-1）对大鼠的治疗对脂质没有明显影响。血浆尿素和尿酸水平为CCl_4 + Vit。与CCl_4组相比，C组明显增加。这些结果表明，维生素C通过其抗氧化特性，对CCl_4诱导的氧化应激引起的肝毒性和肾脏毒性具有保护作用，可以减少脂质过氧化并使谷胱甘肽水平正常化，并改善了生化标志物的变化。而且，Vit。 C在经CCl_4处理的大鼠中显示出降血脂作用。

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