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首页> 外文期刊>Journal of pharmacology & toxicology. >Assessment of Antihepatotoxic Effect of Cuscuta californica against Carbon Tetra Chloride Induced Liver Damage in Wistar Rats
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Assessment of Antihepatotoxic Effect of Cuscuta californica against Carbon Tetra Chloride Induced Liver Damage in Wistar Rats

机译：夜蛾对四氯化碳诱导的Wistar大鼠肝损伤的抗肝毒性作用评估

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摘要

The plant Cuscuta californica was traditionally used to treat liver, spleen and gallbladder disorders such as jaundice and to support liver function in other Western herbalism. The present study was conducted to evaluate hepatoprotective effect of methanolic extracts of Cuscuta californica at doses of 100, 200 and 400 mg kg~(-1) day~(-1) and aqueous extract at dose 400 mg kg"1 day"1 orally for 5 days against carbon tetrachloride (CC1_4)- induced liver damage in rats. After injection of CC1_4 on 3rd day and administration of 100 mg kg"1 methanol extract for 5 days slightly increased the liver enzymes and decreased bilirubin concentration. At 200 and 400 mg kg"1 methanol extract and 400 mg kg"1 aqueous extract there was a damage and necrosis in the liver. The characteristic trait of extracts of plant is its toxicity on liver, kidney and changes on growth rate. This toxicity was accompanied by increase in the activity of aspartate transaminase (AST), alkaline phosphatase (ALP) and alanine transaminase (ALT), decreased concentration of albumin in serum and granulocytes and increased value of lymphocytes in blood. This study revealed that the plant C. californica did not showed any hepatoprotective activity but slight hepatotoxicity to the treated animals.
机译：传统上，Cuscuta californica植物用于治疗肝脏，脾脏和胆囊疾病，如黄疸病，并在其他西方草药中支持肝脏功能。本研究旨在评估100、200和400 mg kg〜（-1）day〜（-1）剂量的加仑Cu草的甲醇提取物和400 mg kg“ 1天” 1口服的水提取物的保肝作用。持续5天以抵抗四氯化碳（CC1_4）诱导的大鼠肝损伤。在第3天注射CC1_4并给予100 mg kg“ 1甲醇提取物5天后，肝酶略有增加，胆红素浓度降低。在200和400 mg kg” 1甲醇提取物和400 mg kg“ 1水提取物中植物提取物的特征是其对肝，肾的毒性和生长速率的变化，这种毒性伴随着天冬氨酸转氨酶（AST），碱性磷酸酶（ALP）和丙氨酸转氨酶（ALT），降低血清和粒细胞中白蛋白的浓度，增加血液中淋巴细胞的价值，这项研究表明，C。californica植物没有显示任何肝保护活性，但对被治疗动物有轻微的肝毒性。

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