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首页> 外文期刊>Journal of pharmacology & toxicology. >Cytogenetic Effects of Technical and Formulated Tribenuron-methyl on Rat Bone-marrow Cells
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Cytogenetic Effects of Technical and Formulated Tribenuron-methyl on Rat Bone-marrow Cells

机译：技术和配方苯磺​​隆对大鼠骨髓细胞的细胞遗传学作用

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摘要

World Health Organization emphasized the necessity of evaluating toxic hazard of the formulated pesticides. So, in current study, the genotoxic and cytotoxic potential of technical and formulated tribenuron-methyl herbicide were investigated in male rat bone-marrow cells, using the Structural Chromosomal Aberration (SCA) and micronucleus (MN) test systems. Technical and formulated tribenuron-methyl were administrated to rats as single or repeated oral doses of 5 (NOAEL), 25, 50 and 100 mg kg~(-1) b.wt. for 21 days at 48 h intervals. Results showed that repetitive dose of formulated tribenuron-methyl (100 mg a.i. kg"1 b.wt.) induced significant decrease in the mitotic activity. After repetitive doses, the frequency of total chromosomal aberrations was statistically significant (p<=0.05-0.01) at two higher doses, 50 and 100 mg a.i. kg~(-1) b.wt. of formulated tribenuron-methyl as well as significant increase (p<=0.05) at high dose (100 mg a.i. kg~(-1) b.wt.) of technical tribenuron-methyl. The frequency of MN was statistically significant at two higher doses, 50 (p<0.05) and 100 (p<=0.01) mg a.i. kg"1 b.wt. of formulated tribenuron-methyl. Our results reveal that tribenuron-methyl has a clastogenic/genotoxic potential as measured by the bone marrow CA and MN tests in rats. The partial differences of the genotoxic effects obtained with pure and commercial tribenuron-methyl indicate that commercial formulations may contain additional hazardous compounds. Therefore, it is important in assessing the real human hazard from pesticides to investigate not only the active principle but also the commercial formulations used in agriculture.
机译：世界卫生组织强调必须评估所配制农药的毒性危害。因此，在当前的研究中，使用结构染色体畸变（SCA）和微核（MN）测试系统对雄性大鼠骨髓细胞中技术和配制的苯磺隆甲基除草剂的遗传毒性和细胞毒性潜力进行了研究。以单次或重复口服剂量分别以5（NOAEL），25、50和100 mg kg〜（-1）b.wt.的剂量向大鼠给药工业和配方的苯磺隆甲基。每48小时间隔21天。结果表明，重复剂量的甲基苯磺隆制剂（100 mg ai kg“ 1 b.wt.）导致有丝分裂活性显着降低。重复剂量后，总染色体畸变的频率具有统计学意义（p <= 0.05-0.01） ）在两种较高剂量下，分别以50和100 mg ai kg〜（-1）b.wt.配制的苯磺隆甲基化以及在高剂量（100 mg ai kg〜（-1）下显着增加（p <= 0.05）在两个较高剂量下，MN的频率在统计学上显着，分别为50（p <0.05）和100（p <= 0.01）mg ai kg“ 1 b.wt.。配制的苯磺隆甲基。我们的研究结果表明，通过大鼠的骨髓CA和MN试验测得的苯丁隆甲基具有杀伤/遗传毒性的潜力。用纯的和市售的苯磺隆甲基获得的遗传毒性作用的部分差异表明，市售制剂可能含有其他有害化合物。因此，重要的是评估农药的实际人为危害，不仅要研究活性成分，而且要研究农业中使用的商业配方。

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