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首页> 外文期刊>Journal of pharmacology & toxicology. >Antiamnesie and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice
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Antiamnesie and Antioxidant Effect of Acacia catechu-catechin in Normal, Aged and Scopolamine Challenged Cognitive Deficit Mice

机译：相思树儿茶素儿茶素对正常，老年和东pol碱攻击的认知缺陷小鼠的抗记忆和抗氧化作用

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摘要

In the present study Acacia catechu-Catechin (CTN) was evaluated for antiamnesic and antioxidant activity using various in vivo models. Scopolamine and natural aging were used to induce experimental amnesia in mice. The tested does of CTN (40, 20 and 10 mg kg"1) significantly enhanced the learning capacity and retention of memory in Passive Shock Avoidance and Spatial Water cage exteroceptive behavioural models. Pre-treatment with CTN restored the increased levels of lip id peroxidation and reduced glutathione due to scopolamine and natural aging. A dose dependent CTN (40, 20 and 10 mg kg"1) antioxidant activity of Thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) in whole brain was seen, which were comparable to Standard Piracetam (400 mg kg"1). Hence, it is worthwhile to explore the potential of this Acacia, catechu-Catechin in the management of Neurodegenerative disorders of the type Alzheimer's disease.
机译：在本研究中，使用多种体内模型评估了阿拉伯树胶儿茶-儿茶素（CTN）的抗记忆和抗氧化活性。使用东pol碱和自然衰老诱导小鼠实验性健忘症。经测试的CTN（40、20和10 mg kg“ 1）可以显着增强被动避震和空间水笼子抽搐行为模型中的学习能力和记忆力。CTN预处理可以恢复增加的脂质过氧化水平并观察到全脑中剂量依赖性的CTN（40、20和10 mg kg“ 1）硫代巴比妥酸反应性物质（TBARS）的抗氧化活性和还原型谷胱甘肽（GSH），具有可比性到标准吡拉西坦（400 mg kg“ 1）。因此，值得探索这种相思树儿茶酚儿茶素在治疗阿尔茨海默氏病神经退行性疾病中的潜力。

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