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首页> 外文期刊>Journal of pharmacology & toxicology. >Acute and Sub Chronic Oral Toxicity Assessment of the Ethanolic Extract from the Rind oi Nephelium lappaceum in Rats
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Acute and Sub Chronic Oral Toxicity Assessment of the Ethanolic Extract from the Rind oi Nephelium lappaceum in Rats

机译：大鼠l肾上腺乙醇提取物的急性和亚慢性口服毒性评估

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摘要

Nephelium lappaceum is a tropical fruit native to Malaysia. The rind of N. lappaceum, is having extremely high antioxidant and free radical scavenging activities. The ethanol extract from the rind of Nephelium lappaceum was evaluated for acute and sub-chronic toxicity study in Sprague Dawley rats. In the acute study, a single oral administration of N. lappaceum rind extract (50, 200, 1000 and 2000 mg kg-1) was administered to rats for 14 days. In the sub chronic toxicity study, the extract was administered to rats (500, 2000 mg kg-1) for 28 days. There was no mortality, or adverse effects observed in rats. There was no significant difference observed in relative organ weights and the biochemical analysis (serum urea, creatinine, ALP, AST and total protein). Histological observation of liver and kidney also did not reveal any significant changes. In conclusion, present study showed that the lethal dose of ethanol extract of Nephelium lappaceum rind is more than 2000 mg kg-1 and there is a huge margin of safety for the therapeutic use. No-observed-adverse-effect-level (NOEL) of the extract is considered to be up to 2000 mg kg"1 day-1 for 28 days in rats.
机译：猪app是马来西亚的热带水果。猪笼草的外皮具有极高的抗氧化剂和清除自由基的活性。评估了兰l皮外皮中的乙醇提取物在Sprague Dawley大鼠中的急性和亚慢性毒性研究。在急性研究中，对大鼠单次口服鸦尾草皮提取物（50、200、1000和2000 mg kg-1），持续14天。在亚慢性毒性研究中，将提取物给予大鼠（500，2000 mg kg-1）28天。在大鼠中没有观察到死亡率或不良反应。相对器官重量和生化分析（血清尿素，肌酐，ALP，AST和总蛋白）没有观察到显着差异。肝和肾的组织学观察也未发现任何明显变化。综上所述，目前的研究表明，枸杞子皮乙醇提取物的致死剂量超过2000 mg kg-1，在治疗上有很大的安全余地。在大鼠中，在28天中，提取物的未观察到的不良反应水平（NOEL）被认为高达2000 mg kg“ 1 day-1”。

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