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首页> 外文期刊>Journal of pharmacological sciences. >Malfunction of Vascular Control in Lifestyle-Related Diseases: Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite.
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Malfunction of Vascular Control in Lifestyle-Related Diseases: Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite.

机译：与生活方式有关的疾病中的血管控制功能失调：由饮食亚硝酸盐形成的系统性血红蛋白一氧化氮复合物（HbNO）。

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摘要

Nitric oxide (NO) has many physiological functions. It is believed to be produced from L-arginine by nitric oxide synthase (NOS), and nitrite and nitrate are waste forms of it. By the way, nitrate and nitrite are abundant in vegetables and fruits, especially leafy vegetables and pickled vegetables. Orally-ingested nitrate is changed to nitrite by micro-organelles living in the hypopharynx area, and nitrite is expected to change to NO in the stomach due to its low pH. Indeed, some researchers reported that NO is produced in the gastric cavity, although few reports mentioned the physiological meanings of this NO formation. Therefore, we investigated whether the nitrite-derived NO can shift to the circulation and acts like NOS-derived NO does in tissues. We adopted a stable isotope of nitrite ((15)NO(2)(-)) in order to distinguish between the endogenous nitrite and the exogenously administered one and measured nitrosyl hemoglobin (HbNO) as an index of circulating NO using electron paramagnetic resonance spectroscopy. It appeared that the oral administration of (15)N-nitrite formed the Hb(15)NO in rat blood and decreased the blood pressure of chronic L-NAME treated rats. Our findings suggest that the intake of nitrite (or nitrate)-rich foods such as vegetables and fruits would alter the systemic HbNO dynamism, resulting in the improvement of cardiovascular diseases.
机译：一氧化氮（NO）具有许多生理功能。据信它是由一氧化氮合酶（NOS）由L-精氨酸生产的，亚硝酸盐和硝酸盐是其废料。顺便说一下，蔬菜水果中的硝酸盐和亚硝酸盐含量很高，尤其是多叶蔬菜和腌制蔬菜。口服的硝酸盐会被下咽区域的微生物转化为亚硝酸盐，由于其pH值低，预计亚硝酸盐在胃中会转变为NO。确实，一些研究人员报告说胃中会产生NO，尽管很少有报道提到这种NO形成的生理意义。因此，我们调查了亚硝酸盐衍生的NO是否可以转移到循环系统中，并像组织中的NOS衍生的NO一样起作用。我们采用亚硝酸盐（（15）NO（2）（-））的稳定同位素，以区分内源性亚硝酸盐和外源性亚硝酸盐，并使用电子顺磁共振光谱法测量亚硝酰基血红蛋白（HbNO）作为循环NO的指标。看来口服（15）N亚硝酸盐会在大鼠血液中形成Hb（15）NO，并降低慢性L-NAME治疗的大鼠的血压。我们的研究结果表明，摄入富含亚硝酸盐（或硝酸盐）的蔬菜和水果等食物会改变全身性HbNO活力，从而改善心血管疾病。

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