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首页> 外文期刊>Journal of pharmacological sciences. >Antitumor Activity of the Methanol Extract of Hypericum hookerianum Stem Against Ehrlich Ascites Carcinoma in Swiss Albino Mice.
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Antitumor Activity of the Methanol Extract of Hypericum hookerianum Stem Against Ehrlich Ascites Carcinoma in Swiss Albino Mice.

机译：贯叶连翘的甲醇提取物对瑞士白化病小鼠的腹水性腹水癌的抗肿瘤活性。

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摘要

A large number of plants belonging to the Hypericum family are known to possess strong antitumor properties. The methanol extract of H. hookerianum Wight and Arnott stem (MEHH) exhibited potent in vitro cytotoxic activity against various cancerous cell lines. In the present study, the high performance liquid chromatography (HPLC) standardized MEHH was tested for in vivo antitumor properties against Ehrlich ascites carcinoma (EAC) tumor bearing mice at 100, 200, and 400 mg/kg body weight doses given orally once daily for 14 days. The results indicate that administration of the extract not only increased the survival of animals with ascites tumor, decreased the body weight induced by the tumor burden, and reduced packed cell volume and viable tissue cell count, but also altered many hematological parameters changed during tumor progression, indicating the potent antitumor nature of the extract. Among the three doses tested, the 200 mg/kg body weight dose was found to be the most potent.
机译：已知属于金丝桃属家族的许多植物具有强的抗肿瘤特性。 H. hookerianum Wight和Arnott茎（MEHH）的甲醇提取物表现出对各种癌细胞系的有效体外细胞毒性活性。在本研究中，以每天一次口服100、200和400 mg / kg体重的剂量对高效液相色谱（HPLC）标准化的MEHH进行了抗艾氏腹水癌（EAC）荷瘤小鼠的体内抗肿瘤特性的测试。 14天结果表明，提取物的给药不仅增加了患有腹水肿瘤的动物的存活率，降低了由肿瘤负荷引起的体重，减少了细胞堆积量和活组织细胞计数，而且改变了肿瘤进展过程中改变的许多血液学参数，表明提取物具有强大的抗肿瘤特性。在三种测试剂量中，发现200 mg / kg体重剂量最有效。

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