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首页> 外文期刊>Clinics in laboratory medicine >Myeloid malignancies: myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia.
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Myeloid malignancies: myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia.

机译：骨髓恶性肿瘤：骨髓增生异常综合症，骨髓增生性疾病和急性髓性白血病。

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摘要

As hematopoietic cells proceed in differentiation from stem cells to committed progenitors to later stage mature forms, they undergo a sequence of morphologic, immunophenotypic, and functional changes that are a consequence of interaction between the underlying cellular genetic program and environmental cues, are linear for each cell lineage, and result in a pattern of antigenic expression related to lineage and stage of maturation. The antigenic patterns characteristic of normal maturation have been elucidated systematically and found invariant between individuals. Deviation from this pattern is a hallmark of hematopoietic neoplasia. Application of these principles to myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia is presented and illustrated.
机译：随着造血细胞从干细胞向定型祖细胞分化到后期成熟形式的进行，它们经历了一系列的形态学，免疫表型和功能性变化，这些变化是基础细胞遗传程序和环境提示之间相互作用的结果，每个线性变化细胞谱系，并导致与谱系和成熟阶段有关的抗原表达模式。正常成熟的抗原模式已经系统地阐明，并且发现个体之间是不变的。偏离这种模式是造血肿瘤的标志。介绍并说明了这些原理在骨髓增生异常综合症，骨髓增生性疾病和急性髓性白血病中的应用。

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