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首页> 外文期刊>Journal of pharmacological sciences. >Long-term effects of high doses of nicotine on feeding behavior and brain nitric oxide synthase activity in female mice.
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Long-term effects of high doses of nicotine on feeding behavior and brain nitric oxide synthase activity in female mice.

机译：高剂量尼古丁对雌性小鼠进食行为和脑中一氧化氮合酶活性的长期影响。

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摘要

We studied the long-term effects of repeated doses of nicotine, causing dependence, 120 days after its withdrawal on feeding behavior and on brain nitric oxide (NO) formation in female mice. Nicotine dependence was induced by subcutaneous (s.c.) nicotine injection (2 mg/kg, four injections daily) for 14 days. Daily food intake was evaluated for the entire observational period (120 days). Moreover, 30, 60, and 120 days after nicotine withdrawal, we evaluated food intake, nitriteitrate levels, and nitric oxide synthase (NOS) activity and expression in the hypothalamus after food deprivation (24 h). In animals in which nicotine dependence was induced (NM), daily food intake was similar to that of controls (M). However, following food deprivation, NM mice showed i) a significant increase in food intake, ii) changes in weight gain and in hypothalamic nitriteitrate levels, and iii) enhancement of hypothalamic neuronal NOS (nNOS) activity. Results indicate that high doses of nicotine producing dependence induce long-term changes in feeding behavior consequent to food deprivation associated to alterations in the brain nitrergic system.
机译：我们研究了尼古丁重复剂量对戒断120天后对雌性小鼠的进食行为和脑中一氧化氮（NO）形成的依赖性的长期影响。通过皮下（s.c.）尼古丁注射（2mg / kg，每天四次注射）诱导尼古丁依赖性14天。在整个观察期内（120天）评估每日食物摄入量。此外，在尼古丁戒断后30、60和120天，我们评估了食物摄入（24小时）后下丘脑的食物摄入量，亚硝酸盐/硝酸盐水平以及一氧化氮合酶（NOS）活性和表达。在诱发尼古丁依赖（NM）的动物中，每日食物摄入量与对照组（M）相似。但是，在食物缺乏后，NM小鼠显示i）食物摄入量显着增加，ii）体重增加和下丘脑亚硝酸盐/硝酸盐水平的变化，以及iii）下丘脑神经元NOS（nNOS）活性增强。结果表明，高剂量的尼古丁产生依赖性可导致长期摄食行为的变化，这是由于与脑硝化系统改变有关的食物匮乏所致。

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