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首页> 外文期刊>Journal of pharmacological sciences. >Complicated interaction between psychostimulants and morphine in expression of phenotype of behavior in the dopaminergic system of BALB/c mice.
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Complicated interaction between psychostimulants and morphine in expression of phenotype of behavior in the dopaminergic system of BALB/c mice.

机译：在多巴胺能系统BALB / c小鼠行为表型的表达中，精神兴奋剂和吗啡之间的相互作用复杂。

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It is believed that BALB/c mice appear to be less sensitive to the locomotor effects of abused drugs compared to other strains, and several behaviors induced by abused drugs depend on genetic factors. The present study was designed to investigate the effects of the interaction between psychostimulants and morphine on behavior in BALB/c mice. Morphine and cocaine induced hyperlocomotion and hypolocomotion, respectively, while methamphetamine did not affect locomotor activity and high doses of methamphetamine significantly increased self-injurious behavior. Cocaine or methamphetamine increased the effects of morphine on locomotor behavior. Haloperidol (a dopamine-receptor antagonist) attenuated the hyperlocomotion induced by the combination of cocaine or methamphetamine plus morphine. These results indicate that the synergistic effects of methamphetamine or cocaine and morphine on locomotor activity are mediated through enhancement of the dopaminergic system and that combinations of psychostimulants and morphine enhance the locomotor activity in BALB/c mice. On the other hand, morphine completely attenuated methamphetamine-induced self-injurious behavior. Furthermore, a low dose (0.01 mg/kg) of haloperidol significantly increased the effects of methamphetamine and morphine on the locomotor activity. Hyperlocomotion induced by psychostimulants is mediated by the mesolimbic dopaminergic system, whereas stereotyped behaviors is mediated by the nigrostriatal dopaminergic system. Our findings suggest that balances of the activation of dopaminergic neurons (between mesolimbic and nigrostriatal systems) may play an important role to engender corresponding behavioral outcomes in BALB/c mice.
机译：可以相信，与其他毒株相比，BALB / c小鼠似乎对滥用药物的运动效果不敏感，并且滥用药物引起的几种行为取决于遗传因素。本研究旨在研究精神刺激剂和吗啡之间的相互作用对BALB / c小鼠行为的影响。吗啡和可卡因分别引起运动过度和运动减退，而甲基苯丙胺不影响运动活性，高剂量的甲基苯丙胺会明显增加自残行为。可卡因或甲基苯丙胺增加了吗啡对运动行为的影响。氟哌啶醇（一种多巴胺受体拮抗剂）减弱了可卡因或甲基苯丙胺加吗啡联合使用所引起的运动过度。这些结果表明，甲基苯丙胺或可卡因和吗啡对运动活性的协同作用是通过增强多巴胺能系统介导的，并且精神刺激药和吗啡的组合可增强BALB / c小鼠的运动活性。另一方面，吗啡完全减弱了甲基苯丙胺引起的自我伤害行为。此外，低剂量（0.01 mg / kg）的氟哌啶醇显着增加了甲基苯丙胺和吗啡对运动活性的影响。精神兴奋剂诱发的超速运动是由中脑边缘多巴胺能系统介导的，而刻板印象的行为是由黑质纹状体多巴胺能系统介导的。我们的发现表明，多巴胺能神经元激活的平衡（在中脑边缘和黑质纹状体系统之间）可能在引起BALB / c小鼠相应的行为结果中起重要作用。

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