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首页> 外文期刊>Journal of pharmacological sciences. >Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle.
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Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle.

机译:硫化氢导致小鼠支气管平滑肌松弛。

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摘要

We investigated the effects of NaHS, a hydrogen sulfide (H(2)S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 - 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 - 3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K(+) channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H(2)S in the respiratory system.
机译:我们调查了硫化氢(H(2)S)供体NaHS对孤立的小鼠和豚鼠支气管环张力的影响。未经预收缩的NaHS在0.01-10 mM对那些制剂的口气没有影响。当制剂与卡巴胆碱预收缩时,NaHS在0.1-3 mM处强烈松弛小鼠环,但在豚鼠环中仅产生轻微松弛。 NaHS诱导的小鼠支气管松弛对ATP敏感K(+)通道,可溶性鸟苷酸环化酶,环氧合酶(COX)-1或COX-2的抑制剂和速激肽受体的拮抗剂具有抗性。因此,NaHS引起小鼠支气管扩张,提示H(2)S在呼吸系统中的可能作用。

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